Ziemann U, Steinhoff B J, Tergau F, Paulus W
Department of Clinical Neurophysiology, University of Gottingen, Germany.
Epilepsy Res. 1998 Mar;30(1):11-30. doi: 10.1016/s0920-1211(97)00079-x.
This paper reviews the current role of transcranial magnetic stimulation (TMS) in epilepsy research. After a brief introduction to the technical principles, the physiology and the safety aspects of TMS, emphasis is put on how human cortex excitability can be assessed by TMS and how this may improve our understanding of pathophysiological mechanisms in epilepsy and the mode of action of antiepileptic drugs (AEDs). Also, potential therapeutical applications of TMS are reviewed. For all aspects of this paper, a clear distinction was made between single-/paired-pulse TMS and repetitive TMS, since these two techniques have fundamentally different scopes and applications.
本文综述了经颅磁刺激（TMS）在癫痫研究中的当前作用。在简要介绍TMS的技术原理、生理学及安全性方面之后，重点阐述了如何通过TMS评估人类皮质兴奋性，以及这如何增进我们对癫痫病理生理机制和抗癫痫药物（AEDs）作用方式的理解。此外，还综述了TMS的潜在治疗应用。对于本文的所有方面，单脉冲/双脉冲TMS与重复经颅磁刺激（rTMS）之间有明确区分，因为这两种技术在基本范围和应用上有根本差异。
