Okabe S, Takeuchi K, Honda K, Takagi K
Digestion. 1976;14(1):85-8. doi: 10.1159/000197802.
A chronic gastric ulcer model was produced in rats by the subserosal injection of 20% acetic acid solution (0.015 ml) in order to examine whether (1) acetylsalicylic acid (ASA) irritates the chronic gastric ulcer in active or healed or diminished stage, (2) L-glutamine, given together with ASA, inhibits the adverse effect of ASA. Oral ASA 200 mg/kg/day, given in two divided doses for 10 consecutive days, apparently delayed the healing of the gastric ulcer and irritated the healed ulcer to reulcerate. L-Glutamine, 1,500 mg/kg/day, which was given together with ASA in two divided doses, markedly protected the gastric ulcer both in active and healed stages from the deleterious activity of ASA.
通过在大鼠浆膜下注射20%醋酸溶液（0.015毫升）建立慢性胃溃疡模型，以研究：（1）乙酰水杨酸（ASA）是否会刺激处于活动期、愈合期或缩小期的慢性胃溃疡；（2）与ASA同时给予的L-谷氨酰胺是否能抑制ASA的不良反应。口服ASA 200毫克/千克/天，分两次给药，连续给药10天，明显延迟了胃溃疡的愈合，并使已愈合的溃疡再次溃疡。L-谷氨酰胺1500毫克/千克/天，与ASA分两次同时给药，在活动期和愈合期均显著保护胃溃疡免受ASA的有害作用。
