Creutzfeldt W, Ebert R, Arnold R, Freichs H, Brown J C
Diabetologia. 1976 Jul;12(3):279-86. doi: 10.1007/BF00422096.
The response of serum immunoreactive gastric inhibitory polypeptide (IR-GIP), gastrin (IRG) and insulin (IRI) to a mixed standard meal was measured in 15 controls, 6 patients with coeliac disease, 26 patients with chronic pancreatitis and partial duodenopancreatectomy (Whipple's procedure). Serum levels of IR-GIP, IRG and IRI were significantly reduced in patients with coeliac disease. The serum glucose increase was significantly smaller only during the first hour after the meal. Since small intestinal GIP- and G-cells are situated mainly in the glands of duodenal and jejunal mucosa their absolute number is not significantly reduced in coeliac disease. It is suggested that the release of IR-GIP and duodenal IRG is influenced by the rate of absorption of nutrients. In patients with chronic pancreatitis the IR-GIP release is significantly greater than in controls, the IRG release normal and the IRI response delayed. After Whipple's procedure the IR-GIP response is increased significantly while the IRG secretion is abolished. This demonstrates that the duodenum is not necessary for GIP release and that pancreatic and jejunal gastrin are without clinical significance.
在15名对照者、6名乳糜泻患者、26名慢性胰腺炎患者以及接受十二指肠胰腺部分切除术（惠普尔手术）的患者中，测量了血清免疫反应性胃抑制多肽（IR - GIP）、胃泌素（IRG）和胰岛素（IRI）对混合标准餐的反应。乳糜泻患者的血清IR - GIP、IRG和IRI水平显著降低。仅在餐后第一小时内，血清葡萄糖的升高明显较小。由于小肠GIP细胞和G细胞主要位于十二指肠和空肠黏膜的腺体中，在乳糜泻中它们的绝对数量并未显著减少。提示IR - GIP和十二指肠IRG的释放受营养物质吸收速率的影响。在慢性胰腺炎患者中，IR - GIP的释放显著高于对照者，IRG释放正常，IRI反应延迟。惠普尔手术后，IR - GIP反应显著增加，而IRG分泌消失。这表明十二指肠对于GIP释放并非必需，并且胰腺和空肠胃泌素无临床意义。
