van Lenthe F J, van Mechelen W, Kemper H C, Twisk J W
Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit Amsterdam, The Netherlands.
Am J Epidemiol. 1998 Apr 1;147(7):686-93. doi: 10.1093/oxfordjournals.aje.a009510.
The association between the change in a central pattern of body fat and blood pressure and lipoprotein levels was investigated longitudinally in a healthy population of young males and females over 15 years. The subjects (males, n = 84; females, n = 98), participants in the Amsterdam Growth and Health Study, were measured six times between the mean ages of 13 and 27 years. As an indicator of a central pattern of body fat, subscapular/triceps skinfold ratio (S/T ratio) was used as an independent variable. Systolic blood pressure (SBP), diastolic blood pressure (DBP), total serum cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and TC/HDL-C ratio were used as dependent variables. Longitudinal associations were analyzed by generalized estimating equations (GEE) in which data of the six periods of measurement were included simultaneously. Between ages 13 and 27 years, and after adjustment for the sum of four skinfolds, physical activity, smoking, and alcohol intake, the increase of the S/T ratio was significantly associated with an increase in SBP in males and females and with a decrease in level of HDL-C in males only. The change in central pattern of body fat negatively affects the change in established risk factors for cardiovascular diseases early in life.
在一个健康的年轻男性和女性群体中，对身体脂肪中心模式的变化与血压及脂蛋白水平之间的关联进行了长达15年的纵向研究。这些受试者（男性84名，女性98名）是阿姆斯特丹生长与健康研究的参与者，在平均年龄13岁至27岁之间接受了6次测量。作为身体脂肪中心模式的一个指标，肩胛下/肱三头肌皮褶厚度比（S/T比）被用作自变量。收缩压（SBP）、舒张压（DBP）、总血清胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）以及TC/HDL-C比被用作因变量。纵向关联通过广义估计方程（GEE）进行分析，其中六个测量时间段的数据被同时纳入。在13岁至27岁之间，并且在对四处皮褶厚度总和、身体活动、吸烟和饮酒量进行调整之后，S/T比的增加与男性和女性的SBP升高显著相关，并且仅与男性HDL-C水平的降低相关。身体脂肪中心模式的变化在生命早期对心血管疾病既定危险因素的变化产生负面影响。
