Spring K R
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892-1603, USA.
Annu Rev Physiol. 1998;60:105-19. doi: 10.1146/annurev.physiol.60.1.105.
The mechanism of fluid transport by leaky epithelia and the route taken by the transported fluid are in dispute. A consideration of current mathematical models for coupling of solutes and water, as well as the methodologies for the study of fluid transport, shows that local osmosis best accounts for water movement. Although it seems virtually certain that the tight junctions are water permeable, the fraction of absorbed fluid that crosses the tight junction cannot yet be determined with confidence.
渗漏上皮细胞的液体转运机制以及转运液体所经过的途径仍存在争议。对当前溶质与水耦合的数学模型以及液体转运研究方法的思考表明，局部渗透最能解释水的移动。尽管紧密连接几乎肯定是透水的，但穿过紧密连接的吸收液体的比例尚无法确定。
