肺炎链球菌分离株中大环内酯类、林可酰胺类及链阳菌素耐药机制的发生率与特征
Prevalence and characterization of the mechanisms of macrolide, lincosamide, and streptogramin resistance in isolates of Streptococcus pneumoniae.
作者信息
Johnston N J, De Azavedo J C, Kellner J D, Low D E
机构信息
Department of Microbiology, Mount Sinai and Princess Margaret Hospitals, and the University of Toronto, Ontario.
出版信息
Antimicrob Agents Chemother. 1998 Sep;42(9):2425-6. doi: 10.1128/AAC.42.9.2425.
Abstract
Of a total of 147 erythromycin-resistant Streptococcus pneumoniae isolates, 64 (43.5%) were resistant to erythromycin, clindamycin, and streptogramin B (MLSB phenotype), 57 of which possessed the ermB gene. Eighty-two (55.8%) were resistant to erythromycin alone (M phenotype), 81 of which possessed the mefE gene. One was erythromycin and streptogramin B resistant but susceptible to clindamycin (MS phenotype) and possessed neither the erm gene nor the mefE gene.
摘要
在总共147株对红霉素耐药的肺炎链球菌分离株中，64株（43.5%）对红霉素、克林霉素和链阳菌素B耐药（MLSB表型），其中57株携带ermB基因。82株（55.8%）仅对红霉素耐药（M表型），其中81株携带mefE基因。1株对红霉素和链阳菌素B耐药，但对克林霉素敏感（MS表型），既不携带erm基因也不携带mefE基因。
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