Warner J T, Cowan F J, Dunstan F D, Evans W D, Webb D K, Gregory J W
Department of Child Health, University of Wales College of Medicine, Cardiff, UK.
Acta Paediatr. 1998 Mar;87(3):244-9. doi: 10.1080/08035259850157264.
Dual-energy X-ray absorptiometry (DEXA) is a rapid and precise technique for the assessment of bone mineralization in children. Interpretation of the results in growing children is complex as results are influenced by age, body size (height and weight) and puberty. Conventionally, bone mineral data derived from DEXA have been presented as an areal density [BMD; bone mineral content (BMC, g)/projected bone area (BA, cm2)], yet this fails to account for changes in BMC that result from changes in age, body size or pubertal development. Measurement of BMC and BA of the whole body, lumbar spine and left hip were made in 58 healthy boys and girls using DEXA. The relationship between BMC and BA was curvilinear, with the best fit being that of a power model (BMD = BMC/BAlambda, where lambda is the exponent to which BA is raised in order to remove its influence on BMC). The value of lambda changed when measures of body size and puberty were taken into account (e.g. for lumbar spine from 1.66 to 1.49). Predictive formulae for BMC were produced using regression analysis and based on the variables of age, body size and pubertal development. This provides a method for interpreting the measured BMC which is independent of such variables and a constant reference range for children aged 6-18 y.
双能X线吸收法（DEXA）是一种用于评估儿童骨矿化的快速且精确的技术。由于生长中儿童的骨密度测量结果受年龄、身体大小（身高和体重）以及青春期的影响，对其结果的解读较为复杂。传统上，DEXA得出的骨矿数据一直以面密度[骨密度（BMD）；骨矿物质含量（BMC，克）/投影骨面积（BA，平方厘米）]来表示，但这无法解释因年龄、身体大小或青春期发育变化而导致的BMC变化。使用DEXA对58名健康男孩和女孩进行了全身、腰椎和左髋部的BMC及BA测量。BMC与BA之间的关系呈曲线，最佳拟合为幂模型（BMD = BMC/BAlambda，其中lambda是BA的指数，用于消除其对BMC的影响）。当考虑身体大小和青春期指标时，lambda值会发生变化（例如，腰椎的lambda值从1.66变为1.49）。使用回归分析并基于年龄、身体大小和青春期发育变量生成了BMC的预测公式。这提供了一种独立于这些变量来解读测量所得BMC的方法，以及一个适用于6至18岁儿童的恒定参考范围。
