Shaari C M, Wu B L, Biller H F, Chuang S K, Sanders I
Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA.
Otolaryngol Head Neck Surg. 1998 Apr;118(4):452-7. doi: 10.1177/019459989811800404.
The objective of this study was to determine whether botulinum toxin types A and D reduced the production of saliva from the submandibular glands of 18 dogs. The left submandibular glands of 8 dogs were injected with increasing doses of botulinum type A toxin (range 10 to 70 units), and the left glands of 10 dogs were injected with botulinum type D toxin (50 or 100 units). The right gland of each dog was injected with equivalent volumes of saline solution to serve as control. Six days after the injection, the lingual nerve was electrically stimulated for 10 minutes (3 mAmp, 20 Hz). The resulting volume of saliva was collected and weighed. Overall, the glands injected with types A or D toxin produced significantly less saliva than comparable glands injected with saline solution. Six of 8 dogs injected with type A toxin showed a significant decrease in saliva production (range 10.1% to 19.2%, one-sided p value = 0.0375) when compared with the controls. Nine of 10 dogs injected with type D toxin demonstrated a highly significant reduction in saliva production (total average decrease = 60%, two-sided pvalue = 0.001) when compared with the controls. We concluded that intraglandular injections of botulinum toxin types A and D significantly reduced the production of saliva from canine submandibular glands. The potential applications of intraglandular injections of botulinum toxin are discussed.
本研究的目的是确定A型和D型肉毒杆菌毒素是否能减少18只狗下颌下腺的唾液分泌。给8只狗的左侧下颌下腺注射递增剂量的A型肉毒杆菌毒素（范围为10至70单位），给10只狗的左侧腺体注射D型肉毒杆菌毒素（50或100单位）。给每只狗的右侧腺体注射等量的盐溶液作为对照。注射后6天，对舌神经进行10分钟的电刺激（3毫安，20赫兹）。收集并称重产生的唾液量。总体而言，注射A型或D型毒素的腺体产生的唾液明显少于注射盐溶液的对照腺体。与对照组相比，8只注射A型毒素的狗中有6只唾液分泌显著减少（范围为10.1%至19.2%，单侧p值=0.0375）。与对照组相比，10只注射D型毒素的狗中有9只唾液分泌显著减少（平均总减少率=60%，双侧p值=0.001）。我们得出结论，腺内注射A型和D型肉毒杆菌毒素可显著减少犬下颌下腺的唾液分泌。文中还讨论了腺内注射肉毒杆菌毒素的潜在应用。
