Coskun Berna Uslu, Savk Hayati, Cicek Esin Derin, Basak Tulay, Basak Muzaffer, Dadas Burhan
Department of Otorhinolaryngology, Sisli Etfal Training and Education Hospital, Istanbul, Turkey.
Eur Arch Otorhinolaryngol. 2007 Jul;264(7):783-7. doi: 10.1007/s00405-007-0254-8. Epub 2007 Feb 7.
The aim of the study was to correlate the sonographic features of Botox A injection in rat submandibular gland with the histopathological changes. Fifteen Wistar albino rats were randomly assigned to 2 groups. Group 1 (control group) consisted of 5 animals not given any substance. Group 2 was divided as "a" and "b" each consisting of 5 animals. A median cervical incision has been performed to the rats in group 2 and 2.5 U Botulinum toxin A reconstituted 0.1 ml physiologic saline was injected into the right gland. Sonograms were obtained before the application, at the first day of the Botox A application, in addition to group 2a on the 14th day, and on 28th day to group 2b. Gland size was lower in group 2a and 2b comparing to control group. The gland size of group 2b was lower than group 2a. There was no change in vascularization. There was no other histopathological change except lymphocytic infiltration in group 2. It was observed that Botox A injection does not have a direct effect on the cells in submandibular gland but it causes a homogenic shrinking in gland size without atrophy.
本研究的目的是将大鼠下颌下腺肉毒杆菌毒素A注射的超声特征与组织病理学变化相关联。15只Wistar白化大鼠被随机分为2组。第1组（对照组）由5只未给予任何物质的动物组成。第2组分为“a”和“b”两组，每组各5只动物。对第2组大鼠进行颈部正中切口，并将2.5 U用0.1 ml生理盐水复溶的肉毒杆菌毒素A注射到右侧腺体中。在注射前、肉毒杆菌毒素A注射的第一天获取超声图像，此外，第2a组在第14天、第2b组在第28天也获取超声图像。与对照组相比，第2a组和第2b组的腺体大小较小。第2b组的腺体大小低于第2a组。血管化没有变化。第2组除淋巴细胞浸润外没有其他组织病理学变化。观察到肉毒杆菌毒素A注射对下颌下腺细胞没有直接影响，但会导致腺体大小均匀缩小而无萎缩。
