特定染色体的单体性决定了L-山梨糖的利用：白色念珠菌中的一种新型调控机制。
Monosomy of a specific chromosome determines L-sorbose utilization: a novel regulatory mechanism in Candida albicans.
作者信息
Janbon G, Sherman F, Rustchenko E
机构信息
Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, NY 14642, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5150-5. doi: 10.1073/pnas.95.9.5150.
Abstract
We report the identification of the gene, SOU1, required for L-sorbose assimilation in Candida albicans. The level of the expression of SOU1 is determined by the copy number of chromosome III (also denoted chromosome 5), such that monosomic strains assimilate L-sorbose, whereas disomic strains do not, in spite of the fact that SOU1 is not on this chromosome. We suggest that C. albicans contains a resource of potentially beneficial genes that are activated by changes in chromosome number, and that this elaborate mechanism regulates the utilization of food supplies and possibly other important functions, thus representing a novel general means for regulating gene expression in microbes.
摘要
我们报告了白色念珠菌中L-山梨糖同化所需基因SOU1的鉴定。SOU1的表达水平由III号染色体（也称为5号染色体）的拷贝数决定，因此单体菌株能够同化L-山梨糖，而二体菌株则不能，尽管SOU1并不在这条染色体上。我们认为白色念珠菌含有一系列潜在有益基因，这些基因可由染色体数目的变化激活，并且这种精细的机制调节食物供应的利用以及可能的其他重要功能，从而代表了一种调节微生物基因表达的新的通用方式。
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