Regulation of DNA polymerase exonucleolytic proofreading activity: studies of bacteriophage T4 "antimutator" DNA polymerases.
作者信息
Reha-Krantz L J
机构信息
Department of Biological Sciences, University of Alberta, Edmonton, Canada.
出版信息
Genetics. 1998 Apr;148(4):1551-7. doi: 10.1093/genetics/148.4.1551.
Abstract
摘要
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本文引用的文献
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The spectrum of acridine resistant mutants of bacteriophage T4 reveals cryptic effects of the tsL141 DNA polymerase allele on spontaneous mutagenesis.噬菌体T4吖啶抗性突变体的谱系揭示了tsL141 DNA聚合酶等位基因对自发诱变的隐秘影响。
Genetics. 1998 Apr;148(4):1655-65. doi: 10.1093/genetics/148.4.1655.
2
Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69.来自噬菌体RB69的α家族复制DNA聚合酶的晶体结构。
Cell. 1997 Jun 27;89(7):1087-99. doi: 10.1016/s0092-8674(00)80296-2.
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Using 2-aminopurine fluorescence and mutational analysis to demonstrate an active role of bacteriophage T4 DNA polymerase in strand separation required for 3' --> 5'-exonuclease activity.利用2-氨基嘌呤荧光和突变分析来证明噬菌体T4 DNA聚合酶在3'→5'核酸外切酶活性所需的链分离中发挥的积极作用。
J Biol Chem. 1996 Nov 15;271(46):28903-11. doi: 10.1074/jbc.271.46.28903.
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Crystal structures of an NH2-terminal fragment of T4 DNA polymerase and its complexes with single-stranded DNA and with divalent metal ions.T4 DNA聚合酶氨基端片段及其与单链DNA和二价金属离子复合物的晶体结构。
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6
Use of genetic analyses to probe structure, function, and dynamics of bacteriophage T4 DNA polymerase.利用基因分析探究噬菌体T4 DNA聚合酶的结构、功能及动力学。
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Construction and characterization of a bacteriophage T4 DNA polymerase deficient in 3'-->5' exonuclease activity.缺乏3'→5'核酸外切酶活性的噬菌体T4 DNA聚合酶的构建与特性分析
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General antimutators are improbable.一般的抗突变剂是不太可能存在的。
J Mol Biol. 1993 Jan 5;229(1):8-13. doi: 10.1006/jmbi.1993.1002.
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Mutants of Escherichia coli with increased fidelity of DNA replication.DNA复制保真度提高的大肠杆菌突变体。
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Nucleotide repeats. Slippery DNA and diseases.核苷酸重复序列。易滑DNA与疾病。
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