• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Regulation of DNA polymerase exonucleolytic proofreading activity: studies of bacteriophage T4 "antimutator" DNA polymerases.DNA聚合酶核酸外切校正活性的调控：噬菌体T4“抗突变”DNA聚合酶的研究
Genetics. 1998 Apr;148(4):1551-7. doi: 10.1093/genetics/148.4.1551.
2
Selection of bacteriophage T4 antimutator DNA polymerases: a link between proofreading and sensitivity to phosphonoacetic acid.噬菌体T4抗突变DNA聚合酶的选择：校对与对膦乙酸敏感性之间的联系
Mutat Res. 1996 Feb 19;350(1):9-16. doi: 10.1016/0027-5107(95)00085-2.
3
The proofreading pathway of bacteriophage T4 DNA polymerase.噬菌体T4 DNA聚合酶的校对途径。
J Biol Chem. 1998 Sep 4;273(36):22969-76. doi: 10.1074/jbc.273.36.22969.
4
Genetic and biochemical studies of bacteriophage T4 DNA polymerase 3'-->5'-exonuclease activity.噬菌体T4 DNA聚合酶3'→5'核酸外切酶活性的遗传与生化研究
J Biol Chem. 1993 Dec 25;268(36):27100-8.
5
Learning about DNA polymerase function by studying antimutator DNA polymerases.通过研究抗突变DNA聚合酶来了解DNA聚合酶的功能。
Trends Biochem Sci. 1995 Apr;20(4):136-40. doi: 10.1016/s0968-0004(00)88987-2.
6
DNA polymerase fidelity: from genetics toward a biochemical understanding.DNA聚合酶保真度：从遗传学走向生化理解
Genetics. 1998 Apr;148(4):1475-82. doi: 10.1093/genetics/148.4.1475.
7
Inactivation of the 3'-5' exonuclease of the replicative T4 DNA polymerase allows translesion DNA synthesis at an abasic site.复制性T4 DNA聚合酶的3'-5'核酸外切酶失活可使无碱基位点处进行跨损伤DNA合成。
J Mol Biol. 2004 Mar 5;336(5):1023-34. doi: 10.1016/j.jmb.2004.01.005.
8
Motif A of bacteriophage T4 DNA polymerase: role in primer extension and DNA replication fidelity. Isolation of new antimutator and mutator DNA polymerases.噬菌体T4 DNA聚合酶的基序A：在引物延伸和DNA复制保真度中的作用。新型抗突变和致突变DNA聚合酶的分离。
J Biol Chem. 1994 Feb 25;269(8):5635-43.
9
Stopped-flow fluorescence study of precatalytic primer strand base-unstacking transitions in the exonuclease cleft of bacteriophage T4 DNA polymerase.噬菌体T4 DNA聚合酶外切酶裂隙中预催化引物链碱基解堆叠转变的停流荧光研究。
Biochemistry. 1998 Jul 14;37(28):10156-63. doi: 10.1021/bi9800754.
10
Exonuclease-polymerase active site partitioning of primer-template DNA strands and equilibrium Mg2+ binding properties of bacteriophage T4 DNA polymerase.噬菌体T4 DNA聚合酶的引物-模板DNA链的核酸外切酶-聚合酶活性位点分区及Mg2+平衡结合特性
Biochemistry. 1998 Jul 14;37(28):10144-55. doi: 10.1021/bi980074b.

引用本文的文献

1
T4 DNA polymerase prevents deleterious on-target DNA damage and enhances precise CRISPR editing.T4 DNA 聚合酶可预防有害的靶 DNA 损伤，并提高精确的 CRISPR 编辑效率。
EMBO J. 2024 Sep;43(17):3733-3751. doi: 10.1038/s44318-024-00158-6. Epub 2024 Jul 22.
2
Polγ coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity.聚合酶 γ 协调 DNA 合成和校对以确保线粒体基因组的完整性。
Nat Struct Mol Biol. 2023 Jun;30(6):812-823. doi: 10.1038/s41594-023-00980-2. Epub 2023 May 18.
3
Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ variants at low dNTP levels.增强的聚合酶活性使得与癌症相关的 DNA 聚合酶 ϵ 变体能够在低 dNTP 水平下高效合成。
Nucleic Acids Res. 2022 Aug 12;50(14):8023-8040. doi: 10.1093/nar/gkac602.
4
Cdc42-Specific GTPase-Activating Protein Rga1 Squelches Crosstalk between the High-Osmolarity Glycerol (HOG) and Mating Pheromone Response MAPK Pathways.CDC42 特异性鸟苷三磷酸酶激活蛋白 Rga1 抑制高渗透压甘油 (HOG) 和交配信息素反应丝裂原活化蛋白激酶 (MAPK) 途径之间的串扰。
Biomolecules. 2021 Oct 17;11(10):1530. doi: 10.3390/biom11101530.
5
Remdesivir triphosphate blocks DNA synthesis and increases exonucleolysis by the replicative mitochondrial DNA polymerase, Pol γ.瑞德西韦三磷酸通过抑制复制型线粒体 DNA 聚合酶 Pol γ 来阻断 DNA 合成并增加核酸外切酶活性。
Mitochondrion. 2021 Nov;61:147-158. doi: 10.1016/j.mito.2021.09.010. Epub 2021 Oct 5.
6
Mutation Rates, Mutation Frequencies, and Proofreading-Repair Activities in RNA Virus Genetics.RNA 病毒遗传学中的突变率、突变频率和校对修复活性。
Viruses. 2021 Sep 21;13(9):1882. doi: 10.3390/v13091882.
7
John W. (Jan) Drake: A Biochemical View of a Geneticist .约翰 W.（简）·德雷克：遗传学家的生化视角。
Genetics. 2020 Dec;216(4):827-836. doi: 10.1534/genetics.120.303813.
8
Excessive excision of correct nucleotides during DNA synthesis explained by replication hurdles.复制障碍解释了 DNA 合成过程中正确核苷酸的过度切除。
EMBO J. 2020 Mar 16;39(6):e103367. doi: 10.15252/embj.2019103367. Epub 2020 Feb 9.
9
Inhibiting DNA Polymerases as a Therapeutic Intervention against Cancer.抑制DNA聚合酶作为一种抗癌治疗干预手段。
Front Mol Biosci. 2017 Nov 21;4:78. doi: 10.3389/fmolb.2017.00078. eCollection 2017.
10
Molecular events during translocation and proofreading extracted from 200 static structures of DNA polymerase.从200个DNA聚合酶静态结构中提取的易位和校对过程中的分子事件。
Nucleic Acids Res. 2016 Sep 6;44(15):7457-74. doi: 10.1093/nar/gkw555. Epub 2016 Jun 20.

本文引用的文献

1
The spectrum of acridine resistant mutants of bacteriophage T4 reveals cryptic effects of the tsL141 DNA polymerase allele on spontaneous mutagenesis.噬菌体T4吖啶抗性突变体的谱系揭示了tsL141 DNA聚合酶等位基因对自发诱变的隐秘影响。
Genetics. 1998 Apr;148(4):1655-65. doi: 10.1093/genetics/148.4.1655.
2
Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69.来自噬菌体RB69的α家族复制DNA聚合酶的晶体结构。
Cell. 1997 Jun 27;89(7):1087-99. doi: 10.1016/s0092-8674(00)80296-2.
3
Using 2-aminopurine fluorescence and mutational analysis to demonstrate an active role of bacteriophage T4 DNA polymerase in strand separation required for 3' --> 5'-exonuclease activity.利用2-氨基嘌呤荧光和突变分析来证明噬菌体T4 DNA聚合酶在3'→5'核酸外切酶活性所需的链分离中发挥的积极作用。
J Biol Chem. 1996 Nov 15;271(46):28903-11. doi: 10.1074/jbc.271.46.28903.
4
Crystal structures of an NH2-terminal fragment of T4 DNA polymerase and its complexes with single-stranded DNA and with divalent metal ions.T4 DNA聚合酶氨基端片段及其与单链DNA和二价金属离子复合物的晶体结构。
Biochemistry. 1996 Jun 25;35(25):8110-9. doi: 10.1021/bi960178r.
5
Selection of bacteriophage T4 antimutator DNA polymerases: a link between proofreading and sensitivity to phosphonoacetic acid.噬菌体T4抗突变DNA聚合酶的选择：校对与对膦乙酸敏感性之间的联系
Mutat Res. 1996 Feb 19;350(1):9-16. doi: 10.1016/0027-5107(95)00085-2.
6
Use of genetic analyses to probe structure, function, and dynamics of bacteriophage T4 DNA polymerase.利用基因分析探究噬菌体T4 DNA聚合酶的结构、功能及动力学。
Methods Enzymol. 1995;262:323-31. doi: 10.1016/0076-6879(95)62027-3.
7
Construction and characterization of a bacteriophage T4 DNA polymerase deficient in 3'-->5' exonuclease activity.缺乏3'→5'核酸外切酶活性的噬菌体T4 DNA聚合酶的构建与特性分析
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2579-83. doi: 10.1073/pnas.90.7.2579.
8
General antimutators are improbable.一般的抗突变剂是不太可能存在的。
J Mol Biol. 1993 Jan 5;229(1):8-13. doi: 10.1006/jmbi.1993.1002.
9
Mutants of Escherichia coli with increased fidelity of DNA replication.DNA复制保真度提高的大肠杆菌突变体。
Genetics. 1993 Aug;134(4):1023-30. doi: 10.1093/genetics/134.4.1023.
10
Nucleotide repeats. Slippery DNA and diseases.核苷酸重复序列。易滑DNA与疾病。
Nature. 1993 Sep 16;365(6443):207-8. doi: 10.1038/365207a0.

Regulation of DNA polymerase exonucleolytic proofreading activity: studies of bacteriophage T4 "antimutator" DNA polymerases.

作者信息

Reha-Krantz L J

机构信息

Department of Biological Sciences, University of Alberta, Edmonton, Canada.

出版信息

Genetics. 1998 Apr;148(4):1551-7. doi: 10.1093/genetics/148.4.1551.

DOI:10.1093/genetics/148.4.1551
PMID:9560374
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1460113/
Abstract
摘要