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[两种β-2拟交感神经支气管解痉剂对气管上皮杯状细胞分泌物中唾液酸化和硫酸化糖缀合物比例的影响]

[The effect of two beta-2 sympathomimetic bronchospasmolytics on the ratio of sialylated and sulfated glycoconjugates in goblet cell secretions of the tracheal epithelium].

作者信息

Vajner L

机构信息

Ustav histologie a embryologie 2. LF UK, Praha.

出版信息

Cesk Patol. 1998 Jan;34(1):13-6.

PMID:9560878
Abstract

Rabbits were made to inhale two different beta 2 sympathomimetic bronchospasmolytics-salbutamol in Ventolin and phenoterolhydrobromid in Berotec. Changes of secretion contents in tracheal goblet cells were evaluated by classical and lectin histochemistry 30 minutes after administration of drugs. When comparing with control rabbits Ventolin completely suppressed the secretion of neutral glycoconjugates for the benefit of acidic glycoconjugates and completely suppressed sialylation. The administration of Berotec suppressed neutral glycoconjugates, either, but the suppression of sialylation was uncomplete. Berotec was found a less damaging agent.

摘要

让兔子吸入两种不同的β2拟交感神经支气管解痉剂——万托林中的沙丁胺醇和备劳特中的氢溴酸非诺特罗。给药30分钟后,通过经典组织化学和凝集素组织化学评估气管杯状细胞分泌内容物的变化。与对照兔相比,万托林完全抑制了中性糖缀合物的分泌,有利于酸性糖缀合物的分泌,并完全抑制了唾液酸化。备劳特的给药也抑制了中性糖缀合物,但唾液酸化的抑制不完全。发现备劳特是一种危害较小的药物。

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