Toker A
Boston Biomedical Research Institute, MA 02114, USA.
Curr Opin Cell Biol. 1998 Apr;10(2):254-61. doi: 10.1016/s0955-0674(98)80148-8.
Phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) is a membrane phospholipid found in all eukaryotic cells which regulates many important cellular processes, including organization of the cytoskeleton, vesicular trafficking and platelet activation. PtdIns 4,5-P2 can either act as a substrate for lipid kinases and phosphatases, or directly interact with proteins. Recent work has focused on the characterization of the enzymes that regulate PtdIns 4,5-P2 levels in the cell. The discovery of proteins whose activities are modified by interaction with PtdIns 4,5-P2 has helped to redefine the role of this lipid in cell biology.
磷脂酰肌醇-4,5-二磷酸（PtdIns 4,5-P2）是一种存在于所有真核细胞中的膜磷脂，它调节许多重要的细胞过程，包括细胞骨架的组织、囊泡运输和血小板活化。PtdIns 4,5-P2既可以作为脂质激酶和磷酸酶的底物，也可以直接与蛋白质相互作用。最近的研究工作集中在对调节细胞内PtdIns 4,5-P2水平的酶的特性进行表征。那些通过与PtdIns 4,5-P2相互作用而改变活性的蛋白质的发现，有助于重新定义这种脂质在细胞生物学中的作用。
