Vasdev S, Ford C A, Longerich L, Gadag V, Wadhawan S
Department of Medicine, Health Sciences Centre, Memorial University of Newfoundland, St. John's, Canada.
Mol Cell Biochem. 1998 Apr;181(1-2):1-9. doi: 10.1023/a:1006844222963.
Aldehydes are formed in tissues of humans and animals as intermediates of glucose and fructose metabolism and due to lipid peroxidation. N-acetyl cysteine (NAC), an analogue of the dietary amino acid cysteine, binds aldehydes thus preventing their damaging effect on physiological proteins. We measured systolic blood pressure (SBP), platelet cytosolic free calcium [Ca2+]i and tissue aldehyde conjugates in fructose induced hypertensive Wistar-Kyoto (WKY) rats and examined the effect of NAC in the diet on these parameters. Animals age 7 weeks were divided into three groups of 6 animals each and were treated as follows: WKY-control (chow diet and normal drinking water); WKY-Fructose (chow diet and 4% fructose in drinking water); WKY-Fructose+NAC (1.5% NAC in chow diet and 4% fructose in drinking water). After 11 weeks, systolic blood pressure, platelet [Ca2+]i and kidney aldehyde conjugates were all significantly higher in fructose treated rats. NAC treatment prevented these changes. These results suggest that aldehydes may be the cause of fructose induced hypertension and elevated cytosolic free calcium.
醛类在人类和动物组织中作为葡萄糖和果糖代谢的中间产物以及脂质过氧化的产物而形成。N-乙酰半胱氨酸（NAC）是膳食氨基酸半胱氨酸的类似物，它能结合醛类，从而防止其对生理蛋白质产生破坏作用。我们测量了果糖诱导的高血压Wistar-Kyoto（WKY）大鼠的收缩压（SBP）、血小板胞质游离钙[Ca2+]i和组织醛类结合物，并研究了饮食中NAC对这些参数的影响。将7周龄的动物分为三组，每组6只，并进行如下处理：WKY-对照组（普通饲料和正常饮用水）；WKY-果糖组（普通饲料和含4%果糖的饮用水）；WKY-果糖+NAC组（含1.5%NAC的普通饲料和含4%果糖的饮用水）。11周后，果糖处理的大鼠的收缩压、血小板[Ca2+]i和肾脏醛类结合物均显著升高。NAC处理可防止这些变化。这些结果表明，醛类可能是果糖诱导的高血压和胞质游离钙升高的原因。
