Franssen C, Lambrigts D, Degesves S, Coignoul F, Bouillenne C, Lamy M, Meurisse M, Alexandre G P
Université de Liège, Facultés de Médecine vétérinaire, Centre interdisciplinaire de Recherche en Xénotransplantation.
Rev Med Liege. 1998 Feb;53(2):97-102.
In the last few years, transplantation was an area of intense research activity. However, there is a worldwide shortage of donor organs for clinical transplantations. Currently, interest in xenotransplantation research is growing not only because of the increased demand for organs but also because of advances in molecular biology techniques that make possible the genetic or immunological manipulations of the animal donor rather than the human recipient. The better definitions of the mechanisms responsible for xenograft rejection should facilitate appropriate therapeutic strategies for long xenograft survival.
在过去几年中，移植是一个研究活动密集的领域。然而，临床移植的供体器官在全球范围内短缺。目前，对异种移植研究的兴趣正在增加，这不仅是因为对器官的需求增加，还因为分子生物学技术的进步使得对动物供体而非人类受体进行基因或免疫操作成为可能。对异种移植排斥反应机制的更明确界定应有助于制定适当的治疗策略，以实现异种移植的长期存活。
