Al Barzanji A J, Penny S R, Emery J L
J Clin Pathol. 1976 Aug;29(8):675-9. doi: 10.1136/jcp.29.8.675.
The development of germinal centres in the spleen has been estimated in a series of 266 children dying in hospital and 205 children presenting as unexpected death in infancy. The prevalence of germinal centres in the spleen increases rapidly after birth. The percentage of Malpighian bodies showing germinal centres in the spleen is greater in all categories of our classification of death in children dying unexpectedly at home when these are compared with hospital deaths. It is concluded that the children presenting as unexpected death in infancy show no evidence of any deficiency in cellular immunological response and may well have been subjected to increased or precocious antigenic stimulation.
对266名在医院死亡的儿童以及205名表现为婴儿意外死亡的儿童进行了脾脏生发中心发育情况的评估。脾脏生发中心的患病率在出生后迅速上升。与医院死亡病例相比，在我们对在家意外死亡儿童的所有死亡分类中，脾脏中出现生发中心的脾小结百分比更高。得出的结论是，表现为婴儿意外死亡的儿童没有显示出任何细胞免疫反应缺陷的证据，很可能受到了增加的或早熟的抗原刺激。
