高龄对辅助生殖结局的影响。
The influence of advanced age on the outcome of assisted reproduction.
作者信息
Dew J E, Don R A, Hughes G J, Johnson T C, Steigrad S J
机构信息
Department of Reproductive Medicine, Royal Hospital for Women, Randwick, NSW, Australia.
出版信息
J Assist Reprod Genet. 1998 Apr;15(4):210-4. doi: 10.1023/a:1023004503697.
PURPOSE
Our purpose was to determine the influence of age on the outcome of assisted reproduction, with particular interest in women aged 40 years or older.
METHODS
A retrospective review of the 779 patients enrolled in the Royal Hospital for Women Fertility Group fertility program between 1987 and 1994 was performed. The results for women aged 40 years or older were compared with those for women between 36 and 39 years and those younger than 36 years. The main outcome measures were pregnancy rate, pregnancy outcome, fertilization rate, and ovarian response.
RESULTS
Compared with those in younger women, pregnancy rate, pregnancy outcome, fertilization rate, and ovarian response to controlled ovarian stimulation were significantly worse in women aged 40 years or older.
CONCLUSIONS
The outcome of assisted reproduction in women of 40 years of age or older was extremely poor. Compared with those in younger women, pregnancy outcome and ovarian response to controlled ovarian stimulation were significantly worse in women of 40 years or more.
目的
我们的目的是确定年龄对辅助生殖结局的影响，尤其关注40岁及以上的女性。
方法
对1987年至1994年间纳入皇家妇女医院生育组生育计划的779例患者进行回顾性研究。将40岁及以上女性的结果与36至39岁女性以及36岁以下女性的结果进行比较。主要结局指标为妊娠率、妊娠结局、受精率和卵巢反应。
结果
与年轻女性相比，40岁及以上女性的妊娠率、妊娠结局、受精率以及对控制性卵巢刺激的卵巢反应明显更差。
结论
40岁及以上女性的辅助生殖结局极差。与年轻女性相比，40岁及以上女性的妊娠结局和对控制性卵巢刺激的卵巢反应明显更差。
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