年龄、妊娠次数及男性不育状况对使用冷冻供精人工授精后累积受孕率的影响：对某中心10年间2998个治疗周期的分析

Effects of age, gravidity and male infertility status on cumulative conception rates following artificial insemination with cryopreserved donor semen: analysis of 2998 cycles of treatment in one centre over 10 years.

作者信息

Shenfield F, Doyle P, Valentine A, Steele S J, Tan S L

机构信息

Fertility Unit, Middlesex Hospital, London, UK.

出版信息

Hum Reprod. 1993 Jan;8(1):60-4. doi: 10.1093/oxfordjournals.humrep.a137875.

DOI:10.1093/oxfordjournals.humrep.a137875

PMID:8458928

Abstract

The effects of age, gravidity and male infertility status on cumulative conception rates after donor insemination were investigated in an analysis of 2998 treatment cycles undertaken on 443 patients. It was found that the cumulative conception rates after 3, 6 and 12 cycles of treatment were 21, 40 and 62% respectively for patients < 30 years of age compared with 17, 26 and 44% for those aged > or = 30 years (P = 0.008). There was also a significant difference (P < 0.001) in results depending on course of treatment and the cumulative conception rates were 19% after 3 cycles, 33% after 6 cycles and 54% after 12 cycles of treatment in the first course of treatment compared with 40, 67 and 79% respectively in those who returned for subsequent courses of treatment after having achieved a donor insemination pregnancy in the first treatment course. Gravidity and male infertility status (azoospermia or oligozoospermia/asthenozoospermia) did not significantly affect the cumulative conception rates.

摘要

在对443例患者进行的2998个治疗周期分析中，研究了年龄、妊娠次数和男性不育状况对供精人工授精后累积妊娠率的影响。结果发现，年龄<30岁的患者在3个、6个和12个治疗周期后的累积妊娠率分别为21%、40%和62%，而年龄≥30岁的患者分别为17%、26%和44%（P = 0.008）。根据治疗疗程不同，结果也存在显著差异（P < 0.001），首次治疗疗程中，3个周期、6个周期和12个周期后的累积妊娠率分别为19%、33%和54%，而在首次治疗疗程中通过供精人工授精怀孕后返回接受后续治疗疗程的患者，相应的累积妊娠率分别为40%、67%和79%。妊娠次数和男性不育状况（无精子症或少精子症/弱精子症）对累积妊娠率没有显著影响。