Sarquis O, Pieri O S, dos Santos J A
Departamento de Biologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.
Mem Inst Oswaldo Cruz. 1997 Sep-Oct;92(5):619-23. doi: 10.1590/s0074-02761997000500011.
The toxic and behavioural effects of niclosamide (Bayluscide WP 70) on Biomphalaria straminea from a highly endemic area of schistosomiasis in northeastern Brazil were investigated through laboratory bioassays. The LD50 and LD90 were 0.114 mg/l and 0.212 mg/l, respectively. Water-leaving behaviour occurred among 14% to 30% of the snails in the presence of sublethal doses of niclosamide and among 16% of the controls. It was concluded that both the relatively low susceptibility to niclosamide and water-leaving behaviour of local B. straminea may be responsible for the recolonization of transmission foci after mollusciciding. It was suggested that recently improved measures of snail control, such as controlled-release formulations of niclosamide and plant molluscicides should be considered in areas where snail control is recommended.
通过实验室生物测定，研究了氯硝柳胺（拜耳杀螺剂WP 70）对来自巴西东北部血吸虫病高度流行地区的淡黄巴蜗牛的毒性和行为影响。半数致死剂量（LD50）和90%致死剂量（LD90）分别为0.114毫克/升和0.212毫克/升。在存在亚致死剂量氯硝柳胺的情况下，14%至30%的蜗牛出现离水行为，而对照组中这一比例为16%。得出的结论是，当地淡黄巴蜗牛对氯硝柳胺相对较低的敏感性和离水行为可能是杀螺后传播疫源地重新定殖的原因。建议在推荐进行蜗牛控制的地区考虑最近改进的蜗牛控制措施，如氯硝柳胺控释制剂和植物杀螺剂。
