Ankara Numune Egitim ve Arastirma Hastanesi, Noroloji Klinigi, Talatpasa, Bulvari, Samanpazari, Ankara, Turkey.
Neurochem Res. 2012 Jul;37(7):1436-41. doi: 10.1007/s11064-012-0729-x. Epub 2012 Feb 26.
We aimed to investigate possible associations between systemic iron metabolism deficiency and Parkinson's disease, and also to research any possible correlations between stage of the disease and vitamin B12 and folic acid levels. 33 male and 27 female patients diagnosed with idiopathic Parkinson's disease and 22 male and 20 female age- and sex-matched controls were enrolled in the study. Having the diagnosis of secondary Parkinsonism or Parkinson plus syndromes, and for the females, not being in the menopausal stage were considered as exclusion criteria. Recordings of blood samples of both groups collected after 8 h fasts were assessed in terms of serum iron, ferritin levels and iron-binding capacity, vitamin B12 and folic acid levels. The Hoehn and Yahr scale was used to determine the stage of the disease. No statistically significant difference was found with respect to mean serum iron, median serum ferritin levels and median serum iron-binding capacity between the groups. A statistically significant but inverse correlation was found between symptoms' duration and serum iron and ferritin levels. There was no statistically significant difference between the groups with respect to vitamin B12 and folic acid levels. However, a statistically significant but inverse correlation was determined between the patients' vitamin B12 levels and the Hoehn and Yahr scores. As Parkinson's disease progresses, serum iron, ferritin and vitamin B12 levels may decrease. The lower levels of these parameters may be the cause of the progression or may be the result of it.
我们旨在研究系统性铁代谢不足与帕金森病之间的可能关联，并研究疾病分期与维生素 B12 和叶酸水平之间的可能相关性。研究纳入了 33 名男性和 27 名女性特发性帕金森病患者，以及 22 名男性和 20 名女性年龄和性别匹配的对照组。排除标准为诊断为继发性帕金森病或帕金森综合征加征，以及对于女性，未处于绝经阶段。记录两组禁食 8 小时后的血液样本，评估血清铁、铁蛋白水平和铁结合能力、维生素 B12 和叶酸水平。使用 Hoehn 和 Yahr 量表确定疾病分期。两组间血清铁、中位数血清铁蛋白水平和中位数血清铁结合能力的平均值无统计学差异。症状持续时间与血清铁和铁蛋白水平呈统计学显著负相关。两组间维生素 B12 和叶酸水平无统计学差异。然而，患者的维生素 B12 水平与 Hoehn 和 Yahr 评分之间存在统计学显著的负相关。随着帕金森病的进展，血清铁、铁蛋白和维生素 B12 水平可能会降低。这些参数水平较低可能是疾病进展的原因，也可能是其结果。
