淋巴细胞归巢至淋巴结：循环淋巴细胞对高内皮微静脉选择性亲和力的体外证明
Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules.
作者信息
Stamper H B, Woodruff J J
出版信息
J Exp Med. 1976 Sep 1;144(3):828-33. doi: 10.1084/jem.144.3.828.
Abstract
An in vitro model is described for studying the interaction between lymphocytes and high-endothelial venules (HEV) of lymph nodes. Rat or mouse lymphocytes which were layered over fixed sections of syngeneic lymph nodes adhered selectively to the endothelium of HEV but did not bind to other vascular endothelia. Evidence is presented that adherence to HEV in vitro is a property of recirculating lymphocytes and not a characteristic of cells which are unable to home into lymph nodes in vivo.
摘要
描述了一种体外模型，用于研究淋巴细胞与淋巴结高内皮微静脉（HEV）之间的相互作用。将大鼠或小鼠淋巴细胞铺在同基因淋巴结的固定切片上，它们选择性地粘附于HEV的内皮，但不与其他血管内皮结合。有证据表明，体外对HEV的粘附是再循环淋巴细胞的特性，而不是体内不能归巢到淋巴结的细胞的特征。
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Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules.淋巴细胞归巢至淋巴结：循环淋巴细胞对高内皮微静脉选择性亲和力的体外证明
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