Satoh F, Umemura S, Itoh H, Miyajima Y, Tokuda Y, Tajima T, Osamura R Y
Department of Pathology, Tokai University School of Medicine, Isehara, Japan.
Acta Cytol. 1998 Mar-Apr;42(2):413-8. doi: 10.1159/000331629.
Glycogen-rich clear cell carcinoma (GRCC) is a rare variant of breast carcinoma that was first described by Hull et al in 1981. The histologic findings have been described; however, the cytologic characteristics have not been well described.
A 44-year-old female exhibited a palpable mass in her right breast. The fine needle aspirate contained cell clusters in a necrotic background. In addition to carcinoma cells with increased degrees of nuclear atypia, carcinoma cells with less atypia were identified. The tumor cells contained small round or ovoid nuclei and abundant, clear cytoplasm. The tumor, resected by modified radical mastectomy, was diagnosed as GRCC with detection of glycogen accumulation in the cytoplasm.
Although rare, glycogen-rich clear cell carcinoma should be considered in the differential diagnosis of breast cancer in fine needle aspiration cytology to prevent misdiagnosis because of its varied morphologic patterns and less atypical cytologic features.
富含糖原的透明细胞癌（GRCC）是乳腺癌的一种罕见变异类型，于1981年由赫尔等人首次描述。其组织学表现已有报道；然而，细胞学特征尚未得到充分描述。
一名44岁女性右乳可触及肿块。细针穿刺抽吸物在坏死背景中含有细胞团。除了核异型程度增加的癌细胞外，还发现了异型性较小的癌细胞。肿瘤细胞含有小圆形或椭圆形细胞核以及丰富的透明细胞质。通过改良根治性乳房切除术切除的肿瘤被诊断为GRCC，检测发现细胞质中有糖原积聚。
尽管罕见，但在细针穿刺细胞学检查中对乳腺癌进行鉴别诊断时应考虑富含糖原的透明细胞癌，因其形态多样且细胞学特征异型性较小，以免误诊。
