Alexiev B A
Department of Pathology, Alexandrov Hospital, Medical Faculty of Sofia, Bulgaria.
Diagn Cytopathol. 1995 Feb;12(1):62-6. doi: 10.1002/dc.2840120115.
Fine-needle aspiration cytology, immunocytochemistry, and electron microscopic findings are described in a case of glycogen-rich clear cell carcinoma of the breast. The aspirate contained many small and large papillary cell groups and numerous single tall columnar cells with apical cytoplasmic projections and mild to moderate degree of nuclear pleomorphism. Cytochemical localisation of glycogen and immunostaining on air-dried smears with CEA and actin monoclonal antibodies permitted the correct identification and differential diagnosis of the tumor. Electron microscopic examination of the resected specimen confirmed the diagnosis of glycogen-rich clear cell carcinoma. The differential diagnosis and potential diagnostic pitfalls are discussed, and recommendation are offered to prevent misdiagnosis.
本文描述了一例乳腺富含糖原的透明细胞癌的细针穿刺细胞学、免疫细胞化学及电子显微镜检查结果。穿刺物中含有许多大小不一的乳头状细胞团以及众多单个的高柱状细胞，这些细胞具有顶端胞质突起，核多形性为轻度至中度。糖原的细胞化学定位以及使用癌胚抗原（CEA）和肌动蛋白单克隆抗体对空气干燥涂片进行免疫染色有助于对该肿瘤进行正确识别和鉴别诊断。对切除标本的电子显微镜检查证实了富含糖原的透明细胞癌的诊断。文中讨论了鉴别诊断及可能的诊断陷阱，并提出了预防误诊的建议。
