Lewis D G, Kilic A, Ogg C A
Department of Physics, University of Wales, U.K.
Appl Radiat Isot. 1998 May-Jun;49(5-6):707-9. doi: 10.1016/s0969-8043(97)00093-6.
A system has been developed which uses Monte Carlo computer simulations to aid the design and optimisation of a polarised source for in vivo X-ray fluorescence (XRF) analysis of heavy metals: The system is based on a version of the Monte Carlo code EGS4 which includes polarised photon interactions, running on a personal computer. The code was used to construct a model of a clinical polarised XRF system (based on a 300 kV therapy X-ray source) under development at Swansea for the measurement of Pt-based chemotherapy drugs in head and neck tumours. Several simulations were performed to investigate the variation of XRF measurement sensitivity with the material composition and geometry of the system components. Pt XRF spectra generated by the model were found to be in good agreement with experimental data. The optimum operating voltage for the system, predicted by the simulations and confirmed by experiment, was approx. 200 kV. The accuracy of the results obtained to date indicates that this technique will greatly facilitate future design and optimisation studies of a wide variety of XRF systems.
已经开发出一种系统，该系统利用蒙特卡罗计算机模拟来辅助设计和优化用于体内重金属X射线荧光（XRF）分析的偏振源：该系统基于蒙特卡罗代码EGS4的一个版本，其中包括偏振光子相互作用，在个人计算机上运行。该代码用于构建斯旺西正在开发的临床偏振XRF系统（基于300 kV治疗X射线源）的模型，用于测量头颈部肿瘤中基于铂的化疗药物。进行了几次模拟，以研究XRF测量灵敏度随系统组件的材料组成和几何形状的变化。模型生成的铂XRF光谱与实验数据吻合良好。模拟预测并经实验证实的系统最佳工作电压约为200 kV。迄今为止获得的结果的准确性表明，该技术将极大地促进未来对各种XRF系统的设计和优化研究。
