γ干扰素对培养的极化和非极化人上皮细胞中沙眼衣原体生长的不同影响。
Differential effects of gamma interferon on Chlamydia trachomatis growth in polarized and nonpolarized human epithelial cells in culture.
作者信息
Kane C D, Byrne G I
机构信息
Department of Medical Microbiology and Immunology, University of Wisconsin, Madison 53706, USA.
出版信息
Infect Immun. 1998 May;66(5):2349-51. doi: 10.1128/IAI.66.5.2349-2351.1998.
Abstract
The effects of gamma interferon (IFN-gamma) on Chlamydia trachomatis growth in polarized epithelial cells were examined. The range of IFN-gamma concentrations causing aberrant chlamydial growth was wider in polarized than in nonpolarized cultures. Results indicate that chlamydial growth modulation in polarized cells readily leads to persistence and better reflects in vivo conditions.
摘要
研究了γ干扰素（IFN-γ）对极化上皮细胞中沙眼衣原体生长的影响。导致衣原体异常生长的IFN-γ浓度范围在极化培养物中比在非极化培养物中更宽。结果表明，极化细胞中的衣原体生长调节容易导致持续性感染，并且能更好地反映体内情况。
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