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人γ干扰素对沙眼衣原体生长的抑制作用。

Inhibition of growth of Chlamydia trachomatis by human gamma interferon.

作者信息

Shemer Y, Sarov I

出版信息

Infect Immun. 1985 May;48(2):592-6. doi: 10.1128/iai.48.2.592-596.1985.

DOI:10.1128/iai.48.2.592-596.1985
PMID:2985506
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC261392/
Abstract

Treatment of HEp-2 cell cultures with highly purified human gamma interferon before infection resulted in the reduction of Chlamydia trachomatis (L2/434/Bu) infectious particle yield. Electron microscope studies showed that interferon did not affect chlamydial conversion to reticulate bodies but influenced the extent of maturation to elementary bodies. High interferon concentrations (greater than 350 IU/ml) inhibited inclusion body formation and resulted in the appearance of aberrant reticulate bodies.

摘要

在感染前用高度纯化的人γ干扰素处理HEp - 2细胞培养物，可降低沙眼衣原体（L2/434/Bu）感染性颗粒的产量。电子显微镜研究表明，干扰素并不影响衣原体向网状体的转化，但会影响其向原体成熟的程度。高浓度干扰素（大于350 IU/ml）会抑制包涵体形成，并导致异常网状体的出现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/506a/261392/9103702f71fc/iai00116-0331-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/506a/261392/5579eec01027/iai00116-0330-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/506a/261392/9103702f71fc/iai00116-0331-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/506a/261392/5579eec01027/iai00116-0330-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/506a/261392/9103702f71fc/iai00116-0331-a.jpg

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