Kellum J A
Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA.
Kidney Int Suppl. 1998 May;66:S81-6.
There is growing interest in quantitative physical chemical analysis of acid-base physiology among intensivists. Acid-base dilemmas seen in the intensive care unit are not always well addressed by the traditional approaches. Quantitative physical chemical analysis also allows for the exploration of unexplained anion-induced acidosis where the familiar anion gap is insufficient or inaccurate. This approach emphasizes the application of accepted physical chemical principles and identification of independent and dependent acid-base variables. In aqueous solutions, water dissociation is the major source of free hydrogen ions.
重症监护医生对酸碱生理学的定量物理化学分析的兴趣日益浓厚。重症监护病房中出现的酸碱难题，传统方法并不总能很好地解决。定量物理化学分析还可以探索不明原因的阴离子诱导性酸中毒，而传统的阴离子间隙方法并不充分或不准确。这种方法强调应用公认的物理化学原理，并识别独立和相关的酸碱变量。在水溶液中，水的离解是游离氢离子的主要来源。
