Yang K T, Chen H D
Department of Nuclear Medicine, Changhua Christian Hospital, Changhua, Taiwan 500, R.O.C.
Eur J Nucl Med. 1998 May;25(5):515-21. doi: 10.1007/s002590050252.
We evaluated a method for the assessment of left ventricular (LV) function with technetium-99m sestamibi ECG-gated single-photon emission tomography (GSPET). GSPET was performed at rest in 21 patients. Images were reconstructed to obtain end-diastolic (ED) and end-systolic (ES) images. Endocardial and epicardial edges of the left ventricle for the ED and ES images were defined using the gradient images and the algorithm developed. LV wall thickness was measured for the mid-ventricular slices of ED and ES images at 10 degrees intervals. The systolic thickening (ST) and the LV ejection fraction [LVEF(GSPECT)] could be determined. These values were compared with the LV ejection fraction (LVEF) estimated using the gated blood pool method. There was a linear correlation between LVEF and ST (r=0.79), and LVEF and LVEF(GSPET) (r=0.87). Histograms of LV thicknesses were generated. Agreement for evaluation of regional wall motion between the method using histograms of LV thicknesses and the gated blood pool study was 92.8% (kappa=0.75). It is concluded that with an appropriate method for LV edge detection, GSPET with 99mTc-labelled perfusion agents is of use for simultaneous evaluation of myocardial perfusion and assessment of LV function.
我们评估了一种利用锝-99m 甲氧基异丁基异腈心电图门控单光子发射断层扫描（GSPET）评估左心室（LV）功能的方法。对21例患者进行了静息状态下的GSPET检查。重建图像以获取舒张末期（ED）和收缩末期（ES）图像。利用梯度图像和开发的算法确定ED和ES图像上左心室的心内膜和心外膜边缘。在ED和ES图像的心室中部切片上，每隔10度测量一次左心室壁厚度。可以确定收缩期增厚（ST）和左心室射血分数[LVEF（GSPECT）]。将这些值与使用门控血池法估算的左心室射血分数（LVEF）进行比较。LVEF与ST之间存在线性相关性（r = 0.79），LVEF与LVEF（GSPET）之间也存在线性相关性（r = 0.87）。生成了左心室厚度的直方图。使用左心室厚度直方图的方法与门控血池研究在评估局部室壁运动方面的一致性为92.8%（kappa = 0.75）。得出的结论是，采用适当的左心室边缘检测方法，使用99mTc标记的灌注剂进行GSPET可用于同时评估心肌灌注和左心室功能。
