Huong N T, Matsumoto K, Watanabe H
Department of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Japan.
Methods Find Exp Clin Pharmacol. 1998 Jan-Feb;20(1):65-76. doi: 10.1358/mf.1998.20.1.485634.
Majonoside-R2 (MR2), an ocotillol-type saponin, is a dominant saponin component of Vietnamese ginseng. We have investigated the effect of MR2 on behavioral and pathophysiological changes caused by psychological stress such as the communication box paradigm-induced psychological stress (CBP stress), conditioned fear stress and social isolation stress in laboratory animals, and elucidated the possible neuronal mechanisms underlying the action of this compound. MR2 attenuated CBP stress- and conditioned fear stress-induced antinociception, had a protective effect against CBP stress-induced gastric lesions, and restored the hypnotic activity of pentobarbital decreased by CBP stress or social isolation stress to the level of the unstressed controls. Accumulating evidence strongly suggests the involvement of the central opioid, GABAA receptor and corticotropin-releasing factor mechanisms in the effect of MR2. Here we review the antistress effect of Vietnamese ginseng, especially focusing on the effect of MR2 on psychosomatic disorders caused by psychological stress.
人参皂苷-R2（MR2）是一种奥克梯隆型皂苷，是越南人参的主要皂苷成分。我们研究了MR2对实验动物因心理应激（如通讯箱范式诱导的心理应激（CBP应激）、条件性恐惧应激和社会隔离应激）引起的行为和病理生理变化的影响，并阐明了该化合物作用的可能神经元机制。MR2减轻了CBP应激和条件性恐惧应激诱导的抗伤害感受，对CBP应激诱导的胃损伤具有保护作用，并将因CBP应激或社会隔离应激而降低的戊巴比妥催眠活性恢复到未应激对照组的水平。越来越多的证据强烈表明，中枢阿片类、GABAA受体和促肾上腺皮质激素释放因子机制参与了MR2的作用。在此，我们综述越南人参的抗应激作用，尤其关注MR2对心理应激引起的心身疾病的影响。
