Genkin A A
Ter Arkh. 1998;70(3):60-6.
Illustration of potentialities of computer technologies in processing data from case histories
Routine clinical and laboratory data on 263 hemoblastosis patients were processed with the use of the exploring system.
A paradoxical negative relationship was discovered between blood cholesterol and age (R = -0.345, p < 0.00001), and a positive correlation between cholesterol and number of red cells (R = 0.379, p < 0.00001). In comparison of groups with low and high cholesterol, the latter group showed more favourable values of hemoglobin, red cells, other hematological and biochemical parameters. It seems that among hemoblastosis patients and healthy subjects there are subjects with standard age-related changes of cholesterol and paradoxical changes (a negative correlation). The conception about high level of cholesterol as a factor stimulating proliferation of normal and affected cells in patients with hemoblastoses appears doubtful. At least it is not correct to connect a combination hypocholesterolemia + anemia with low pool of dividing cells. On the contrary, hypocholesterolemia in hemoblastoses indicates active tumor process with consequent anemia.
Investigation of paradoxical relationships between age, cholesterol and red cell count (hemoglobin) will help understand general mechanisms of regulation of hemo- and immunogenesis in blood malignancies.
阐述计算机技术在处理病历数据方面的潜力
使用探索系统对263例血液病患者的常规临床和实验室数据进行处理。
发现血液胆固醇与年龄之间存在反常的负相关关系（R = -0.345，p < 0.00001），胆固醇与红细胞数量之间存在正相关关系（R = 0.379，p < 0.00001）。在胆固醇水平低和高的两组之间进行比较时，后一组的血红蛋白、红细胞、其他血液学和生化参数的值更有利。似乎在血液病患者和健康受试者中，存在胆固醇具有标准的年龄相关变化和反常变化（负相关）的受试者。关于高胆固醇水平是刺激血液病患者正常细胞和病变细胞增殖的因素这一概念似乎值得怀疑。至少将低胆固醇血症 + 贫血与低分裂细胞池联系起来是不正确的。相反，血液病中的低胆固醇血症表明存在活跃的肿瘤过程并导致贫血。
研究年龄、胆固醇和红细胞计数（血红蛋白）之间的反常关系将有助于理解血液恶性肿瘤中血液生成和免疫生成的一般调节机制。
