Yamagami Y, Ichikawa K, Mukuno A, Eto H
Department of Dermatology, National Yokohama Hospital, Japan.
J Dermatol. 1998 Mar;25(3):167-70. doi: 10.1111/j.1346-8138.1998.tb02374.x.
We describe a case of Sjögren's syndrome who repeatedly developed annular erythema on her extremities. Her anti-nuclear antibody, anti-SSA/Ro antibody, and anti-SSB/La antibody were all negative. Characteristics of the annular erythema included a tendency to appear on the extremities especially in summer, spontaneous regression after 1-2 weeks, and residual slight pigmentation. The histological findings revealed dermal perivascular lymphocytic infiltration admixed with some neutrophils. Slight exsudative changes were found in the upper dermis. There were no epidermal changes. This case suggests the existence of annular erythema which may not be related to the anti-SSA/Ro or anti-SSB/La antibody. Unknown factors other than those antibodies may be involved in the pathogenesis of the annular erythema.
我们描述了一例干燥综合征患者，其四肢反复出现环形红斑。她的抗核抗体、抗SSA/Ro抗体和抗SSB/La抗体均为阴性。环形红斑的特点包括尤其在夏季易于出现在四肢，1 - 2周后自行消退，以及残留轻微色素沉着。组织学检查结果显示真皮血管周围淋巴细胞浸润，并伴有一些中性粒细胞。在真皮上层发现轻微渗出性改变。未发现表皮变化。该病例提示存在可能与抗SSA/Ro或抗SSB/La抗体无关的环形红斑。除这些抗体外的未知因素可能参与了环形红斑的发病机制。
