Quick C M, Berger D S, Noordergraaf A
Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey 08855-0909, USA.
Am J Physiol. 1998 Apr;274(4):H1393-403. doi: 10.1152/ajpheart.1998.274.4.H1393.
Recently, there has been renewed interest in estimating total arterial compliance. Because it cannot be measured directly, a lumped model is usually applied to derive compliance from aortic pressure and flow. The archetypical model, the classical two-element windkessel, assumes 1) system linearity and 2) infinite pulse wave velocity. To generalize this model, investigators have added more elements and have incorporated nonlinearities. A different approach is taken here. It is assumed that the arterial system 1) is linear and 2) has finite pulse wave velocity. In doing so, the windkessel is generalized by describing compliance as a complex function of frequency that relates input pressure to volume stored. By applying transmission theory, this relationship is shown to be a function of heart rate, peripheral resistance, and pulse wave reflection. Because this pressure-volume relationship is generally not equal to total arterial compliance, it is termed "apparent compliance." This new concept forms the natural counterpart to the established concept of apparent pulse wave velocity.
最近，人们对估算总动脉顺应性重新产生了兴趣。由于无法直接测量，通常应用集总模型从主动脉压力和流量中推导顺应性。典型模型，即经典的二元风箱模型，假定1）系统线性和2）无限脉搏波速度。为了推广该模型，研究人员增加了更多元件并纳入了非线性因素。本文采用了一种不同的方法。假定动脉系统1）是线性的且2）具有有限脉搏波速度。通过将顺应性描述为将输入压力与储存体积相关联的频率的复函数，从而推广了风箱模型。通过应用传输理论，这种关系被证明是心率、外周阻力和脉搏波反射的函数。由于这种压力-体积关系通常不等于总动脉顺应性，因此将其称为“表观顺应性”。这一新概念与已确立的表观脉搏波速度概念自然对应。
