Dimitriou G, Greenough A, Kavvadia V, Laubscher B, Milner A D
Children Nationwide Regional Neonatal Intensive Care Centre, King's College Hospital, London.
Arch Dis Child Fetal Neonatal Ed. 1998 Mar;78(2):F148-50. doi: 10.1136/fn.78.2.f148.
To examine the delivered volume during "high volume strategy" high frequency oscillation, used as rescue treatment in preterm infants; and to identify factors, other than frequency and oscillatory amplitude, influencing the magnitude of volume delivery.
Twenty infants (median gestational age 29 weeks) were studied on 45 occasions. Two oscillator types were used (SensorMedics and SLE). Delivered volume was measured under clinical conditions with the arterial blood gases within a predetermined range. A specially calibrated pneumotachograph system was used.
Overall, the median delivered volume was 2.4 ml/kg (range 1.0 to 3.6 ml/kg); on 32 occasions the delivered volume was greater than 2.0 ml/kg and on seven greater than 3.0 ml/kg. The delivered volume related significantly to disease severity; there was an inverse correlaton between delivered volume and both the oxygenation index (OI) (r = -0.51) and AaDO2 (r = -0.54).
Delivered volume during HFO may, in certain infants, exceed the anatomical dead space, permitting some direct alveolar ventilation.
研究在“高容量策略”高频振荡通气用于早产儿抢救治疗时的输送气量；并确定除频率和振荡幅度外，影响输送气量大小的因素。
对20例婴儿（中位胎龄29周）进行了45次研究。使用了两种振荡通气器类型（SensorMedics和SLE）。在临床条件下，将动脉血气维持在预定范围内时测量输送气量。使用了经过特殊校准的呼吸流速描记系统。
总体而言，中位输送气量为2.4毫升/千克（范围为1.0至3.6毫升/千克）；32次测量中输送气量大于2.0毫升/千克，7次大于3.0毫升/千克。输送气量与疾病严重程度显著相关；输送气量与氧合指数（OI）（r = -0.51）和肺泡-动脉血氧分压差（AaDO2）（r = -0.54）均呈负相关。
在某些婴儿中，高频振荡通气时的输送气量可能超过解剖无效腔，从而实现一定程度的直接肺泡通气。
