Kacmarek Robert M, Malhotra Atul
Department of Anesthesiology, Harvard Medical School, Boston, MA, USA.
Crit Care Med. 2005 Mar;33(3 Suppl):S148-54. doi: 10.1097/01.ccm.0000156786.43935.a0.
Much of the information on the physiologic effects, mechanisms of gas exchange, and potential utility of high-frequency oscillation (HFO) has been acquired in animal studies. Specifically, large animal data have been useful in assessing adult application because large animals present many of the same concerns and challenges as adults.
To review the literature on HFO testing in large animal models, identifying contributions to the understanding of mechanisms of action and the physiology of HFO.
Large animal studies have clarified the mechanisms of gas exchange during HFO, identified approaches to setting mean airway pressure based on lung mechanics, and identified a potentially better approach to applying partial liquid ventilation.
The study of HFO in large animal models has been essential to our understanding of the optimal approach to applying HFO in human studies.
关于高频振荡(HFO)的生理效应、气体交换机制及潜在效用的许多信息是在动物研究中获得的。具体而言,大型动物数据在评估成人应用方面很有用,因为大型动物存在许多与成人相同的问题和挑战。
回顾关于大型动物模型中HFO测试的文献,确定其对理解HFO作用机制和生理学的贡献。
大型动物研究阐明了HFO期间的气体交换机制,确定了基于肺力学设置平均气道压力的方法,并确定了应用部分液体通气的一种可能更好的方法。
在大型动物模型中对HFO的研究对于我们理解在人体研究中应用HFO的最佳方法至关重要。