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利什曼病的药理学

The pharmacology of leishmaniasis.

作者信息

Balaña-Fouce R, Reguera R M, Cubría J C, Ordóñez D

机构信息

Department of Physiology, Pharmacology and Toxicology (INTOXCAL), University of León, Spain.

出版信息

Gen Pharmacol. 1998 Apr;30(4):435-43. doi: 10.1016/s0306-3623(97)00268-1.

DOI:10.1016/s0306-3623(97)00268-1
PMID:9580315
Abstract

The development of new strategies on chemotherapy of parasitic protozoan diseases is one of the most exciting research fields of recent years. World Health Organization (WHO) reports have recognized that the physiology and biochemistry of protozoan parasites and the host-parasite relation are the main targets for the design of new drugs that can be used in the future against these diseases.

摘要

开发针对寄生原生动物疾病的化疗新策略是近年来最令人兴奋的研究领域之一。世界卫生组织(WHO)的报告指出,原生动物寄生虫的生理学和生物化学以及宿主与寄生虫的关系是未来可用于对抗这些疾病的新药设计的主要靶点。

相似文献

1
The pharmacology of leishmaniasis.利什曼病的药理学
Gen Pharmacol. 1998 Apr;30(4):435-43. doi: 10.1016/s0306-3623(97)00268-1.
2
Leishmaniasis: some recent developments in chemotherapy.利什曼病:化疗方面的一些最新进展
J Antimicrob Chemother. 1993 Mar;31(3):327-30. doi: 10.1093/jac/31.3.327.
3
Leishmaniasis.利什曼病
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Advancement in leishmaniasis diagnosis and therapeutics: An update.利什曼病诊断和治疗的进展:更新。
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Liposomal formulations in the pharmacological treatment of leishmaniasis: a review.脂质体制剂在利什曼病药理学治疗中的应用:综述。
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Rational approaches for drug designing against leishmaniasis.针对利什曼病的药物设计的合理方法。
Appl Biochem Biotechnol. 2010 Apr;160(8):2208-18. doi: 10.1007/s12010-009-8764-z. Epub 2009 Sep 8.
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Topoisomerase 1B as a target against leishmaniasis.拓扑异构酶1B作为抗利什曼病的靶点。
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Paromomycin in the treatment of leishmaniasis.巴龙霉素治疗利什曼病
Expert Opin Investig Drugs. 2008 May;17(5):787-94. doi: 10.1517/13543784.17.5.787.
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Clinical status of agents being developed for leishmaniasis.正在研发的用于治疗利什曼病的药物的临床状况。
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Promising therapeutic targets for antileishmanial drugs.抗利什曼原虫药物的潜在治疗靶点。
Expert Opin Ther Targets. 2002 Aug;6(4):407-22. doi: 10.1517/14728222.6.4.407.

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Leishmaniasis: where are we and where are we heading?利什曼病:我们在哪里,我们要往哪里去?
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Nanoparticles for antiparasitic drug delivery.纳米颗粒用于抗寄生虫药物递送。
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Resistance of Leishmania infantum to allopurinol is associated with chromosome and gene copy number variations including decrease in the S-adenosylmethionine synthetase (METK) gene copy number.婴儿利什曼原虫对别嘌醇的耐药性与染色体和基因拷贝数变异有关,包括 S-腺苷甲硫氨酸合成酶 (METK) 基因拷贝数减少。
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