Lee I W, Ahn S K, Choi E H, Lee S H
Department of Dermatology, Yousei University Wonju College of Medicine, Korea.
Br J Dermatol. 1998 Mar;138(3):486-8. doi: 10.1046/j.1365-2133.1998.02130.x.
We report a patient with recurrent generalized itching and urticaria due to inhalation of nicotine in tobacco smoke. A skin prick test with nicotine base (1:10 w/v) was negative but an intradermal test with nicotine base (1:100 w/v) was strongly positive. Intradermal tests with nicotine base (1:100 w/v) performed on 10 healthy controls were negative. A provocation test with a nicotine patch showed the same symptoms and signs including generalized itching, weals and flares, and mild dyspnoea, which occurred when he was exposed to tobacco smoke. Nicotine in tobacco smoke can act as an inhalant allergen and induce urticaria in hypersensitive persons.
我们报告了一名因吸入烟草烟雾中的尼古丁而反复出现全身性瘙痒和荨麻疹的患者。用尼古丁碱（1:10 w/v）进行的皮肤点刺试验为阴性，但用尼古丁碱（1:100 w/v）进行的皮内试验呈强阳性。对10名健康对照者用尼古丁碱（1:100 w/v）进行的皮内试验均为阴性。使用尼古丁贴片进行的激发试验出现了相同的症状和体征，包括全身性瘙痒、风团和潮红，以及轻度呼吸困难，这些症状在他接触烟草烟雾时出现。烟草烟雾中的尼古丁可作为吸入性变应原，在过敏者中诱发荨麻疹。
