Harada A, Okuizumi H, Miyagi N, Genda E
Department of Orthopaedic Surgery, Chubu National Hospital, Obu, Japan.
Spine (Phila Pa 1976). 1998 Apr 15;23(8):857-61; discussion 862. doi: 10.1097/00007632-199804150-00003.
Intervertebral disc area, disc bulge ratio, and bone mineral density were measured in 86 postmenopausal women and the data analyzed.
To examine quantitatively the correlation between intervertebral disc degeneration and bone mass.
In results of previous studies, an inverse correlation between osteoporosis and spondylosis has been reported. In these studies, only radiographic findings were used to evaluate spondylosis; changes in the intervertebral disc itself were not investigated.
To determine bone mass, total-body bone mineral density, lumbar bone mineral density, and age-matched control values of bone mineral density were measured by dual-energy X-ray absorptiometry in all cases. To evaluate intervertebral disc degeneration, disc area and disc bulge ratio (calculated by measuring the areas protruding from lines connecting the middle points of the anterior and posterior borders of the vertebral bodies) were obtained from four discs, using magnetic resonance images of the lumbar spine. The correlation between bone mass data and disc area data was analyzed.
Bone mineral density showed a significant decrease with increasing age. Disc area and disc bulge ratio had no relation to age. There was a negative correlation between total-body bone mineral density, lumbar bone mineral density, and age-matched control values versus disc area, and a positive correlation between all bone mineral density data and the disc bulge ratio.
According to the results of the analysis by disc morphology and bone mass, especially total body bone mineral density, bone mass has an inverse correlation to intervertebral disc degeneration--i.e., reduction and disc bulge--which is important when considering degenerative spinal diseases and osteoporosis.
对86名绝经后女性测量了椎间盘面积、椎间盘膨出率和骨密度，并对数据进行了分析。
定量研究椎间盘退变与骨量之间的相关性。
在以往研究结果中，已有报道称骨质疏松症与脊椎病之间存在负相关。在这些研究中，仅使用影像学表现来评估脊椎病；未对椎间盘本身的变化进行研究。
在所有病例中，采用双能X线吸收法测量全身骨密度、腰椎骨密度以及年龄匹配的骨密度对照值，以确定骨量。为评估椎间盘退变，利用腰椎磁共振成像从四个椎间盘获取椎间盘面积和椎间盘膨出率（通过测量椎体前后缘中点连线向外突出的面积计算得出）。分析骨量数据与椎间盘面积数据之间的相关性。
骨密度随年龄增长显著降低。椎间盘面积和椎间盘膨出率与年龄无关。全身骨密度、腰椎骨密度以及年龄匹配的对照值与椎间盘面积呈负相关，所有骨密度数据与椎间盘膨出率呈正相关。
根据椎间盘形态和骨量的分析结果，尤其是全身骨密度，骨量与椎间盘退变（即椎间盘缩小和膨出）呈负相关，这在考虑退行性脊柱疾病和骨质疏松症时具有重要意义。
