Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.
Spine (Phila Pa 1976). 2012 Nov 1;37(23):E1415-21. doi: 10.1097/BRS.0b013e31826f561e.
Cross-sectional study.
To investigate changes in the morphology of the lumbar vertebrae and intervertebral discs associated with osteoporosis of the spine in elderly subjects.
Osteoporosis is a common condition that primarily affects the elderly with significant impact on quality of life. How exactly osteopenia and osteoporosis influence vertebral and intervertebral disc morphology remains unknown and needs exploration.
A total of 395 community-dwelling ambulatory adults from 67 to 89 years of age were studied. The lumbar bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry. T2-weighted sagittal images of the lumbar spine were obtained using a 1.5-T magnet. For each subject, the anterior height (Ha), middle height (Hm), posterior height (Hp), and anterior-posterior (AP) dimension of the 5 lumbar vertebrae (L1-L5) and 6 intervertebral discs (T12-L1 to L5-S1) were measured. To minimize the age effect, volume of these vertebrae and discs was measured in subgroups of 47 men (mean age = 74 yr, range: 73-75 yr) and 67 women (mean age = 72 yr, range: 71-73 yr). Continuous variables were examined by analysis of covariance after adjustment of height and age.
There was no significant age difference between the groups of normal BMD, osteopenia, and osteoporosis. For the vertebral bodies, lower BMD was associated with a decrease of Ha, Hm, and Hp but not AP in both sexes, leading to an increased biconcavity index. For the discs, lower BMD was associated with a decrease of Ha and Hp, as well as AP, and an increase in Hm in both men and women. The disc biconvexity index was increased. Lower BMD is associated with an overall decrease in both vertebral volume and disc volume.
Lower BMD is associated with a decreasing trend in both lumbar vertebral and disc volumes in elderly subjects but an increase in the Hm of the intervertebral discs.
横断面研究。
研究与老年人脊柱骨质疏松相关的腰椎和椎间盘形态变化。
骨质疏松症是一种常见疾病，主要影响老年人，对生活质量有重大影响。确切地说，骨质疏松症和骨质减少症如何影响椎体和椎间盘形态仍不清楚，需要进一步研究。
研究共纳入了 395 名年龄在 67 至 89 岁之间的社区活动的成年人。腰椎骨矿物质密度（BMD）通过双能 X 射线吸收法测量。使用 1.5T 磁体获得腰椎矢状 T2 加权图像。对于每个受试者，测量了 5 个腰椎（L1-L5）和 6 个椎间盘（T12-L1 至 L5-S1）的前高（Ha）、中高（Hm）、后高（Hp）和前后（AP）尺寸。为了最大限度地减少年龄影响，在 47 名男性（平均年龄=74 岁，范围：73-75 岁）和 67 名女性（平均年龄=72 岁，范围：71-73 岁）亚组中测量了这些椎体和椎间盘的体积。调整身高和年龄后，采用协方差分析检查连续变量。
正常 BMD、骨质疏松症和骨质疏松症组之间无显著年龄差异。对于椎体，男性和女性的较低 BMD 与 Ha、Hm 和 Hp 降低相关，但 AP 不变，导致双凹指数增加。对于椎间盘，男性和女性的较低 BMD 与 Ha 和 Hp 降低以及 AP 增加相关，同时 Hm 增加。椎间盘双凸度指数增加。较低的 BMD 与腰椎和椎间盘体积的整体减少相关。
在老年受试者中，较低的 BMD 与腰椎和椎间盘体积均呈下降趋势相关，但椎间盘的 Hm 增加。
