Rao S S, Welcher K, Zimmerman B, Stumbo P
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA.
Eur J Gastroenterol Hepatol. 1998 Feb;10(2):113-8. doi: 10.1097/00042737-199802000-00003.
It is unclear if ingestion of coffee affects colonic function and if this effect is due to its caffeine content. We investigated the effects of coffee on colonic motor activity in healthy humans.
We performed ambulatory colonic manometry by placing a six-sensor solid-state probe up to the mid-transverse colon in 12 healthy subjects. The following day, over a 10 h period, subjects received four stimuli: 240 ml of three drinks at 45 degrees C in random order: black Colombian coffee (150 mg caffeine), decaffeinated coffee or water and 1000 kcal meal. We analyzed the effects of each stimulant on colonic motor responses.
Caffeinated coffee, decaffeinated coffee and meal induced more activity in the colon with a greater area under the curve of pressure waves (P < 0.01) and a greater number of propagated contractions (P < 0.05) when compared with water. Caffeinated coffee, decaffeinated coffee and meal induced greater (P < 0.05) motor activity in the transverse/descending colon when compared with the rectosigmoid colon. The effects of decaffeinated coffee on colonic motility were not significantly different from those of water or caffeinated coffee and were lower (P < 0.05) than that of a meal.
Caffeinated coffee stimulates colonic motor activity. Its magnitude is similar to a meal, 60% stronger than water and 23% stronger than decaffeinated coffee.
摄入咖啡是否会影响结肠功能以及这种影响是否归因于其咖啡因含量尚不清楚。我们研究了咖啡对健康人结肠运动活性的影响。
我们对12名健康受试者进行了动态结肠测压，将一个六传感器固态探头放置到横结肠中部。第二天，在10小时内，受试者接受四种刺激：随机顺序饮用240毫升45摄氏度的三种饮品：哥伦比亚黑咖啡（含150毫克咖啡因）、脱咖啡因咖啡或水，以及一顿1000千卡的餐食。我们分析了每种刺激对结肠运动反应的影响。
与水相比，含咖啡因的咖啡、脱咖啡因咖啡和餐食可使结肠产生更多活动，压力波曲线下面积更大（P < 0.01），传播性收缩次数更多（P < 0.05）。与直肠乙状结肠相比，含咖啡因的咖啡、脱咖啡因咖啡和餐食在横结肠/降结肠诱导出更大的（P < 0.05）运动活性。脱咖啡因咖啡对结肠动力的影响与水或含咖啡因的咖啡相比无显著差异，且低于餐食的影响（P < 0.05）。
含咖啡因的咖啡可刺激结肠运动活性。其强度与一顿餐食相似，比水强60%，比脱咖啡因咖啡强23%。
