Slobodian M M, Berdyshev G D, Tiulenev V I
Zh Evol Biokhim Fiziol. 1979 Mar-Apr;15(2):131-5.
It has been demonstrated that total homogenates and subcellular fractions of the liver and kidneys of rats exhibit proteolytic activity which specifically digests histone at pH 8.5. The activity of histone hydrolase undergoes age changes in all the subcellular fractions of the liver and kidneys, except the nuclear fraction. Various histone fractions possess different sensitivity to the effect of histone hydrolase. The described enzyme from the liver and kidneys of rats is similar to the histone protease of other vertebrates, although in some respects its properties are somewhat different.
已经证明，大鼠肝脏和肾脏的全匀浆及亚细胞组分表现出蛋白水解活性，该活性在pH 8.5时能特异性消化组蛋白。除细胞核组分外，肝脏和肾脏所有亚细胞组分中的组蛋白水解酶活性均会随年龄变化。各种组蛋白组分对组蛋白水解酶的作用具有不同的敏感性。所述大鼠肝脏和肾脏中的酶与其他脊椎动物的组蛋白蛋白酶相似，尽管在某些方面其性质略有不同。
