Maemura M, Iino Y, Yokoe T, Horiguchi J, Takei H, Koibuchi Y, Horii Y, Takeyoshi I, Ohwada S, Morishita Y
Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan.
Cancer Lett. 1998 Apr 24;126(2):215-20. doi: 10.1016/s0304-3835(98)00014-7.
The serum concentration of hepatocyte growth factor (HGF) was examined in 34 patients with metastatic breast cancer. Although no significant difference was observed between HGF concentration and the site of metastasis, serum HGF levels were slightly higher in patients with liver metastasis and in patients with multiple metastatic sites than in patients with other lesions. Significantly higher levels of serum HGF were observed in patients with progressive metastasis of breast cancer compared with those with stable metastasis. The patients with high HGF levels exhibited a significantly shorter survival rate than those with low HGF levels. Circulating HGF levels may be a useful indicator for the progression of metastatic lesions and the prognosis of patients with metastatic breast cancer.
对34例转移性乳腺癌患者检测了肝细胞生长因子（HGF）的血清浓度。虽然HGF浓度与转移部位之间未观察到显著差异，但肝转移患者和有多个转移部位的患者血清HGF水平略高于有其他病变的患者。与稳定转移的患者相比，乳腺癌进行性转移患者的血清HGF水平显著更高。HGF水平高的患者生存率显著低于HGF水平低的患者。循环HGF水平可能是转移性病变进展及转移性乳腺癌患者预后的有用指标。
