Fukuura T, Miki C, Inoue T, Matsumoto K, Suzuki H
Department of Surgery II, Mie University Medical School, Tsu, Japan.
Br J Cancer. 1998 Aug;78(4):454-9. doi: 10.1038/bjc.1998.514.
To evaluate the clinical significance of serum levels of hepatocyte growth factor (HGF) in colorectal cancer patients, we measured the venous and portal concentrations of HGF in 60 patients. The tissue concentrations in the tumour and adjacent normal mucosa were also determined. The serum HGF concentration for the peripheral venous blood of the patients was significantly higher than that in normal controls. The content of HGF in cancer tissue was also significantly higher than that in normal mucosa, and it was correlated with the serum HGF concentration for the peripheral venous blood. The serum concentration of HGF reflected pathological features, including tumour size and lymph node or liver metastasis, and it showed an association with various preoperative nutritional parameters and the preoperative haemoglobin level. The serum HGF concentration was also correlated with the serum concentrations of immunosuppressive acidic protein and interleukin-6, indices of the host's immunological condition. Serum HGF seems to be a useful index of the disease status of patients with colorectal carcinoma.
为评估肝细胞生长因子（HGF）血清水平在结直肠癌患者中的临床意义，我们检测了60例患者的静脉血和门静脉血中HGF的浓度。同时还测定了肿瘤组织及相邻正常黏膜组织中的HGF浓度。患者外周静脉血中的血清HGF浓度显著高于正常对照组。癌组织中HGF的含量也显著高于正常黏膜组织，且与外周静脉血中的血清HGF浓度相关。血清HGF浓度反映了包括肿瘤大小、淋巴结或肝转移等病理特征，并且与各种术前营养参数及术前血红蛋白水平相关。血清HGF浓度还与免疫抑制酸性蛋白和白细胞介素-6的血清浓度相关，这两个指标反映了宿主的免疫状态。血清HGF似乎是结直肠癌患者疾病状态的一个有用指标。
