Karczewska E, Rycembel Z, Czernicki Z
Neurol Neurochir Pol. 1976 Jul-Aug;10(4):547-50.
The aim of this work was to evaluate the effect of hyperventilation and mannitol on brain volume during neurosurgical operations. The material comprises 30 cases of supratentorial tumours. pO2, pCO2, pH and lactate concentration were determined in the arterial blood and in 7 cases also in the CSF. It was established that hyperventilation sometimes fails to decrease ICP; it was observed that hyperventilation was more effective in decreasing brain volume of the pCO2 level decreased by 14,6 mm Hg on the average. The joint use of hyperventilation and hypertonic mannitol was found to be more effective. Neither of the above methods was effective in the case of cystic tumors.
这项工作的目的是评估神经外科手术期间过度换气和甘露醇对脑容量的影响。材料包括30例幕上肿瘤病例。测定动脉血中的pO2、pCO2、pH和乳酸浓度，7例还测定了脑脊液中的这些指标。结果表明，过度换气有时无法降低颅内压；观察到平均pCO2水平降低14.6毫米汞柱时，过度换气在减少脑容量方面更有效。发现过度换气和高渗甘露醇联合使用更有效。对于囊性肿瘤，上述两种方法均无效。
