Haralambie G
Nutr Metab. 1976;20(1):1-8. doi: 10.1159/000175682.
In order to obtain information on the vitamin B2 status in athletes in training, the following aspects were investigated: in one group of athletes, riboflavinuria at rest, during the autumn and winter months (mean values 23.8 and 9.45 mug/h, respectively); in the second group (n = 18), the activity of the nicotinamide-adenine-dinucleotide-phosphate-dependent red blood cell glutathione reductase (EC 1.6.4.2) and its activation by added flavin adenine dinucleotide. In 8 athletes, activation coefficients higher than 1.25 were found, indicating a biochemical deficiency of riboflavin. Erythrocyte transketolase (EC 2.2.1.1) was activated by more than 25% with added thiamine pyrophosphate in 12 cases. In muscle samples of 10 healthy patients (fresh fractures or removing of metal plates from old fractures), glutathione reductase (mean activity 0.846 +/- 0.458 U/g wet weight) was activated by more than 25% in 5 cases. Administration of 10 mg of riboflavin per os resulted in moderate lowering of neuromuscular irritability (musculi vastus medialis and lateralis quadricipitis) particularly for 0.1-msec rectangular stimuli.
为了获取有关训练中运动员维生素B2状况的信息，对以下方面进行了调查：在一组运动员中，测定了秋季和冬季静息时的核黄素尿（平均值分别为23.8和9.45微克/小时）；在第二组（n = 18）中，测定了烟酰胺腺嘌呤二核苷酸磷酸依赖的红细胞谷胱甘肽还原酶（EC 1.6.4.2）的活性及其对添加的黄素腺嘌呤二核苷酸的激活作用。在8名运动员中，发现激活系数高于1.25，表明核黄素存在生化缺乏。在12例中，添加硫胺素焦磷酸后红细胞转酮醇酶（EC 2.2.1.1）的激活率超过25%。在10名健康患者（新鲜骨折或取出陈旧骨折的金属板）的肌肉样本中，5例谷胱甘肽还原酶（平均活性0.846 +/- 0.458 U/g湿重）的激活率超过25%。口服10毫克核黄素导致神经肌肉兴奋性（股四头肌内侧肌和外侧肌）适度降低，特别是对于0.1毫秒的矩形刺激。
