van den Broek F A, Beynen A C
Agricultural University Wageningen, Small Animal Facility, The Netherlands.
Lab Anim. 1998 Apr;32(2):206-13. doi: 10.1258/002367798780599929.
High-fat and low-fat diets were fed for 24 weeks to two strains of mice differing in susceptibility to the development of dystrophic cardiac calcinosis (DCC). The severity of DCC was assessed by histological examination and measurement of heart calcium concentrations. Plasma and renal tissue mineral levels were also measured. On the basis of macroscopic examination, feeding the high-fat diet did not influence the severity of DCC in the susceptible DBA/2 mice. Heart calcium concentrations were reduced in both strains; in DBA/2 mice more than in DCC-resistant C57BL/6 mice. Cardiac concentrations of magnesium and phosphorus were similar in the two strains of mice and unaffected by the amount of dietary fat. Kidney calcium concentrations were higher in the DBA/2 than in the C57BL/6 mice and the high-fat diet also reduced kidney calcium concentrations in the DBA/2 mice. The amount of dietary fat, at least during growth and maintenance, did not appear to affect the development of DCC in DBA/2 mice.
将高脂饮食和低脂饮食分别喂给两株对营养不良性心脏钙化（DCC）发展易感性不同的小鼠，持续24周。通过组织学检查和心脏钙浓度测量来评估DCC的严重程度。还测量了血浆和肾脏组织的矿物质水平。基于宏观检查，高脂饮食对易感的DBA/2小鼠DCC的严重程度没有影响。两株小鼠的心脏钙浓度均降低；DBA/2小鼠降低的幅度大于抗DCC的C57BL/6小鼠。两株小鼠心脏中的镁和磷浓度相似，且不受饮食脂肪量的影响。DBA/2小鼠的肾脏钙浓度高于C57BL/6小鼠，高脂饮食也降低了DBA/2小鼠的肾脏钙浓度。至少在生长和维持期间，饮食脂肪量似乎不影响DBA/2小鼠DCC的发展。
