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Epstein-Barr virus (EBV) variant with a 30-bp deletion at the carboxyl terminus (amino acids 346-355) of latent membrane protein-1 (LMP1) gene is able to transform cells and evade immune surveillance.

作者信息

Tao Q, Ambinder R F, Swinnen L J

出版信息

Am J Pathol. 1998 May;152(5):1398-9.

PMID:9588909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1858597/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/760e/1858597/c216568ad122/amjpathol00017-0282-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/760e/1858597/c216568ad122/amjpathol00017-0282-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/760e/1858597/c216568ad122/amjpathol00017-0282-a.jpg

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1
Epstein-Barr virus (EBV) variant with a 30-bp deletion at the carboxyl terminus (amino acids 346-355) of latent membrane protein-1 (LMP1) gene is able to transform cells and evade immune surveillance.爱泼斯坦-巴尔病毒（EBV）的潜伏膜蛋白1（LMP1）基因羧基末端（氨基酸346 - 355）存在30个碱基对缺失的变体能够转化细胞并逃避免疫监视。
Am J Pathol. 1998 May;152(5):1398-9.
2
Epstein-Barr virus infection in precursor lesions of nasopharyngeal carcinoma.鼻咽癌前驱病变中的爱泼斯坦-巴尔病毒感染
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Structural variability of the carboxy-terminus of Epstein-Barr virus encoded latent membrane protein 1 gene in Hodgkin's lymphomas.霍奇金淋巴瘤中爱泼斯坦-巴尔病毒编码的潜伏膜蛋白1基因羧基末端的结构变异性
J Med Virol. 2007 Nov;79(11):1730-22. doi: 10.1002/jmv.21020.
4
[C-terminal 30 bp-deletion mutation of latent membrane protein 1 gene of Epstein-barr virus in non-hodgkin's lymphoma].[非霍奇金淋巴瘤中爱泼斯坦-巴尔病毒潜伏膜蛋白1基因C末端30bp缺失突变]
Ai Zheng. 2005 Feb;24(2):145-8.
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Functional analysis of the mutated Epstein-Barr virus oncoprotein LMP1(69del): implications for a new role of naturally occurring LMP1 variants.突变型爱泼斯坦-巴尔病毒癌蛋白LMP1(69del)的功能分析：对天然存在的LMP1变体新作用的启示
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Association between EBNA2 and LMP1 subtypes of Epstein-Barr virus and nasopharyngeal carcinoma in Thais.泰国人身上EB病毒的EBNA2和LMP1亚型与鼻咽癌之间的关联。
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Analyses of Epstein-Barr virus latent membrane protein-1 in Malaysian nasopharyngeal carcinoma: high prevalence of 30-bp deletion, Xho1 polymorphism and evidence of dual infections.马来西亚鼻咽癌中爱泼斯坦-巴尔病毒潜伏膜蛋白-1的分析：30碱基对缺失、Xho1多态性的高流行率及双重感染证据
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Effect of a 10-amino acid deletion on the oncogenic activity of latent membrane protein 1 of Epstein-Barr virus.10个氨基酸缺失对爱泼斯坦-巴尔病毒潜伏膜蛋白1致癌活性的影响。
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Epstein-barr virus (EBV) in healthy carriers: Distribution of genotypes and 30 bp deletion in latent membrane protein-1 (LMP-1) oncogene.健康携带者中的爱泼斯坦-巴尔病毒（EBV）：基因型分布及潜伏膜蛋白-1（LMP-1）癌基因中的30bp缺失
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Distribution of Epstein-Barr virus in the oral cavity of Thais with various oral mucosal conditions.爱泼斯坦-巴尔病毒在患有各种口腔黏膜疾病的泰国人口腔中的分布情况。
Heliyon. 2024 Jan 9;10(2):e24222. doi: 10.1016/j.heliyon.2024.e24222. eCollection 2024 Jan 30.

本文引用的文献

1
Epstein-Barr virus (EBV) in endemic Burkitt's lymphoma: molecular analysis of primary tumor tissue.地方性伯基特淋巴瘤中的爱泼斯坦-巴尔病毒（EBV）：原发性肿瘤组织的分子分析
Blood. 1998 Feb 15;91(4):1373-81.
2
Epstein-Barr virus latent membrane protein-1 oncogene deletion in post-transplantation lymphoproliferative disorders.移植后淋巴组织增生性疾病中爱泼斯坦-巴尔病毒潜伏膜蛋白-1癌基因缺失
Am J Pathol. 1997 Sep;151(3):805-12.
3
Analysis of Epstein-Barr virus gene polymorphisms in normal donors and in virus-associated tumors from different geographic locations.
不同地理位置正常供体及病毒相关肿瘤中爱泼斯坦-巴尔病毒基因多态性分析。
Blood. 1996 Nov 1;88(9):3491-501.
4
Molecular epidemiology of deletions and mutations of the latent membrane protein 1 oncogene of the Epstein-Barr virus in posttransplant lymphoproliferative disorders.移植后淋巴组织增生性疾病中爱泼斯坦-巴尔病毒潜伏膜蛋白1癌基因缺失和突变的分子流行病学
Lab Invest. 1996 Oct;75(4):575-88.
5
Epstein-Barr virus latent membrane protein-1 oncogene deletions: correlations with malignancy in Epstein-Barr virus--associated lymphoproliferative disorders and malignant lymphomas.爱泼斯坦-巴尔病毒潜伏膜蛋白1癌基因缺失：与爱泼斯坦-巴尔病毒相关淋巴增殖性疾病及恶性淋巴瘤中恶性程度的相关性
Blood. 1996 Jul 1;88(1):242-51.
6
Effect of a 10-amino acid deletion on the oncogenic activity of latent membrane protein 1 of Epstein-Barr virus.10个氨基酸缺失对爱泼斯坦-巴尔病毒潜伏膜蛋白1致癌活性的影响。
Oncogene. 1996 May 16;12(10):2129-35.
7
The investigation of Epstein-Barr viral sequences in 41 cases of Burkitt's lymphoma from Egypt: epidemiologic correlations.对来自埃及的41例伯基特淋巴瘤患者的爱泼斯坦-巴尔病毒序列的调查：流行病学相关性
Cancer. 1995 Oct 1;76(7):1245-52. doi: 10.1002/1097-0142(19951001)76:7<1245::aid-cncr2820760723>3.0.co;2-d.
8
The consistent association between Epstein-Barr virus and Hodgkin's disease in children in Kenya.肯尼亚儿童中爱泼斯坦-巴尔病毒与霍奇金淋巴瘤之间的持续关联。
Blood. 1996 May 1;87(9):3828-36.
9
Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue. Type A with a high prevalence of deletions within the latent membrane protein gene.巴西伯基特淋巴瘤及反应性淋巴组织中爱泼斯坦-巴尔病毒的基因分型。A型在潜伏膜蛋白基因内缺失的发生率较高。
Am J Pathol. 1996 Jan;148(1):17-23.
10
Deletions within the LMP1 oncogene of Epstein-Barr virus are clustered in Hodgkin's disease and identical to those observed in nasopharyngeal carcinoma.爱泼斯坦-巴尔病毒LMP1癌基因内的缺失在霍奇金淋巴瘤中呈聚集性，且与鼻咽癌中观察到的缺失相同。
Blood. 1993 Nov 15;82(10):2937-42.