Chen W G, Chen Y Y, Bacchi M M, Bacchi C E, Alvarenga M, Weiss L M
Department of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA.
Am J Pathol. 1996 Jan;148(1):17-23.
Both Epstein-Barr virus (EBV) types A and B are found in endemic Burkitt's lymphoma (BL) occurring in equatorial Africa. We studied 17 cases of Brazilian BL previously demonstrated to be EBV-positive to determine the EBV type as well as the presence of a characteristic 30 bp deletion within the 3' end of the latent membrane protein-1 (LMP-1) gene that may be important to the pathogenesis of several EBV-associated neoplasms. All cases in which the age was known were children. We found type A EBV in 13 of 14 (93%) evaluable cases, and type B in one case. The LMP-1 deletion was found in 12 of 15 (80%) evaluable cases, including the one case of type B EBV, and a similar high prevalence (59%) of the deletion was detected in EBV-positive normal and reactive lymphoid tissues from individuals from the same geographic region. The high proportion of cases associated with type A EBV suggests that immunodeficiency is not an important factor in the pathogenesis of Brazilian BL, in contrast to endemic African BL. The presence of the LMP-1 deletion in a high prevalence in the normal population in this region is unexplained.
在赤道非洲地区流行的伯基特淋巴瘤（BL）中可发现A、B两种类型的爱泼斯坦-巴尔病毒（EBV）。我们研究了17例先前已证实EBV呈阳性的巴西BL病例，以确定EBV的类型以及潜伏膜蛋白-1（LMP-1）基因3'端是否存在一个对几种EBV相关肿瘤发病机制可能很重要的特征性30 bp缺失。所有已知年龄的病例均为儿童。在14例可评估病例中的13例（93%）中发现了A型EBV，1例为B型。在15例可评估病例中的12例（80%）中发现了LMP-1缺失，包括1例B型EBV病例，并且在来自同一地理区域个体的EBV阳性正常和反应性淋巴组织中也检测到了类似的高缺失率（59%）。与非洲地区流行的BL不同，与A型EBV相关的病例比例较高表明免疫缺陷在巴西BL的发病机制中不是一个重要因素。该地区正常人群中LMP-1缺失的高发生率原因不明。
