Ji J, Sun W, Cheng D
Department of Ophthalmology, Qingdao Medical College.
Zhonghua Yan Ke Za Zhi. 1996 Sep;32(5):372-5.
In order to observe the retinal injury by Ca+2 overload under ocular hypertension and the effect of verapamil treatment.
Atomic absorption spectrophotometry and phosphate pyroantemonate (PPA) means were used to observe the changes of rabbit retinal Ca+2 content and the therapeutic effects of verapamil under this situation.
In the ocular hypertensive group, Ca+2 increased from the moment of intraocular pressure elevation, and with prolongation of time, it tended to increase steadily. In comparison with the control group, there were significant differences (P < 0.01). PPA showed that the longer the time, the more obvious swollen the mitochondria and much more calcium deposition in the mitochondria. In the group of rabbits with ocular hypertension having taken verapamil treatment, the Ca+2 content was markedly lower, the changes of mitochondria milder and the Ca+2 deposition in mitochondria less than that of the ocular hypertension group without treatment.
Calcium-overload may be one of the reasons of retinal injury under ocular hypertension, while calcium-blocker may alleviate this injury.
观察高眼压状态下钙离子超载对视网膜的损伤及维拉帕米的治疗作用。
采用原子吸收分光光度法及焦锑酸磷酸法观察兔视网膜钙离子含量变化及维拉帕米在此状态下的治疗效果。
高眼压组眼压升高即刻钙离子含量开始增加，且随时间延长呈稳步上升趋势，与对照组相比差异有显著性（P<0.01）。焦锑酸磷酸法显示，时间越长，线粒体肿胀越明显，线粒体内钙沉积越多。维拉帕米治疗的高眼压兔组钙离子含量明显降低，线粒体变化较轻，线粒体内钙沉积少于未治疗的高眼压组。
钙离子超载可能是高眼压状态下视网膜损伤的原因之一，而钙通道阻滞剂可减轻这种损伤。
