Cruz A A, Coelho R P, Baccega A, Lucchezi M C, Souza A D, Ruiz E E
Department of Ophthalmology, University of São Paulo, School of Medicine of Ribeirão Preto, Brazil.
Ophthalmology. 1998 May;105(5):913-8. doi: 10.1016/S0161-6420(98)95037-0.
This study used image processing techniques to quantify the upper eyelid contour of patients with Graves upper eyelid retraction and congenital blepharoptosis.
The study design was a cross-sectional study.
A total of 29 patients with Graves disease, 22 patients with congenital blepharoptosis, and 50 patients with no history of eye disease participated.
The images of the palpebral fissure of all participants were transferred to a personal computer and processed with NIH Image 1.55 software.
The following parameters were analyzed: the curvature of the upper eyelid contour, the position of the contour peak relative to the midline, and the ratio between the temporal and nasal upper quadrant areas of the palpebral fissure.
All upper eyelid contours could be fitted with second-degree polynomial functions. The mean temporal/nasal area ratio was 1.33 mm in patients with Graves disease, 0.92 mm in patients with blepharoptosis, and 1.04 mm in control subjects. The peak of the upper eyelid contour was found to be lateral to the midline in control subjects (1.05 mm) and in patients with Graves disease (2.09 mm). In patients with blepharoptosis, the peak was 0.69 mm medial to the midline. Overall, the distance between the midpupil and the upper eyelid margin was correlated with several factors: the degree of curvature, the position of the peak of the eyelid contour, and the temporal/nasal area ratio.
In Graves eyelid retraction, the curvature of the upper eyelid is enhanced, the peak of the contour is displaced laterally, and the temporal upper quadrant area is increased. Conversely, in congenital blepharoptosis, the eyelid is almost flat, the peak of the contour is displaced medially, and the upper quadrant area is diminished. The lateral segment of the upper eyelid is more involved than the nasal segment in both Graves upper eyelid retraction and congenital blepharoptosis.
本研究采用图像处理技术对格雷夫斯上睑退缩和先天性上睑下垂患者的上睑轮廓进行量化分析。
本研究设计为横断面研究。
共有29例格雷夫斯病患者、22例先天性上睑下垂患者以及50例无眼部疾病史的患者参与研究。
将所有参与者睑裂的图像传输至个人计算机，并使用美国国立卫生研究院（NIH）Image 1.55软件进行处理。
分析以下参数：上睑轮廓的曲率、轮廓峰值相对于中线的位置以及睑裂颞侧和鼻侧上象限面积之比。
所有上睑轮廓均可用二次多项式函数拟合。格雷夫斯病患者的平均颞侧/鼻侧面积比为1.33mm，上睑下垂患者为0.92mm，对照组为1.04mm。发现对照组（1.05mm）和格雷夫斯病患者（2.09mm）的上睑轮廓峰值位于中线外侧。在上睑下垂患者中，峰值位于中线内侧0.69mm处。总体而言，瞳孔中点与上睑缘之间的距离与几个因素相关：曲率程度、睑轮廓峰值的位置以及颞侧/鼻侧面积比。
在格雷夫斯上睑退缩中，上睑曲率增强，轮廓峰值向外侧移位，颞侧上象限面积增加。相反，在先天性上睑下垂中，眼睑几乎平坦，轮廓峰值向内侧移位，上象限面积减小。在格雷夫斯上睑退缩和先天性上睑下垂中，上睑外侧段比鼻侧段受累更明显。
