Snyder P S
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0126, USA.
J Vet Intern Med. 1998 May-Jun;12(3):157-62. doi: 10.1111/j.1939-1676.1998.tb02111.x.
The efficacy of amlodipine (AML) was tested in hypertensive cats in a placebo-controlled, randomized, blinded clinical trial. Five cats were randomized to receive 0.625 mg AML once daily and 4 cats to receive placebo (PLA) once daily. The average systolic blood pressure (SBP) recorded by the Doppler method on day 0 was 212 +/- 21 mm Hg in the AML group and 216 +/- 32 mm Hg in the PLA group. On day 7, the cats receiving AML had a significantly lower average daily SBP (160 +/- 30 mm Hg) but SBP in the PLA group was unchanged (207 +/- 31 mm Hg). On day 7, all cats receiving PLA and one cat receiving AML were crossed over to the other group because of inadequate response. Blood pressure did not decrease adequately in 3 cats by day 14 (7 days of PLA and 7 days AML) and the treatment code was broken. Each of these cats was subsequently administered 1.25 mg AML daily. Cats requiring 1.25 mg AML once daily (6.1 kg +/- 0.7 kg) weighed significantly more than cats that responded to 0.625 mg AML once daily (4.1 +/- 0.7 kg). The average daily SBP recorded in the 6 cats that completed the study was significantly lower after 16 weeks of treatment (152 +/- 14 mm Hg) compared to day 0 (221 +/- 24 mm Hg). Three cats were euthanized before completion of the study. All 3 cats were responders to AML on day 7. SBPs measured 24 hours after AML administration were similar to the average daily SBP, suggesting that AML effectively controlled SBP for a 24-hour period. AML was shown to be an effective once-daily antihypertensive agent when administered to cats at a dosage of 0.18 +/- 0.03 mg/kg sid.
在一项安慰剂对照、随机、双盲临床试验中，对高血压猫进行了氨氯地平（AML）疗效测试。五只猫被随机分配为每天接受一次0.625毫克AML，四只猫每天接受一次安慰剂（PLA）。通过多普勒法在第0天记录的AML组平均收缩压（SBP）为212±21毫米汞柱，PLA组为216±32毫米汞柱。在第7天，接受AML的猫平均每日SBP显著降低（160±30毫米汞柱），但PLA组的SBP未改变（207±31毫米汞柱）。在第7天，由于反应不足，所有接受PLA的猫和一只接受AML的猫交叉到另一组。到第14天（7天PLA和7天AML）时，3只猫的血压下降不充分，治疗代码被破解。随后，每只猫每天给予1.25毫克AML。每天需要1.25毫克AML的猫（6.1千克±0.7千克）体重显著高于对每天0.625毫克AML有反应的猫（4.1±0.7千克）。与第0天（221±24毫米汞柱）相比，完成研究的6只猫在治疗16周后的平均每日SBP显著降低（152±14毫米汞柱）。三只猫在研究完成前被安乐死。所有3只猫在第7天对AML有反应。AML给药后24小时测量的SBP与平均每日SBP相似，表明AML可有效控制24小时的SBP。当以0.18±0.03毫克/千克的剂量每天一次给猫给药时，AML被证明是一种有效的每日一次抗高血压药物。
